Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20231
Title: Postnatal Expression of Bone Morphogenetic Proteins and Their Receptors in the Mouse Testis
Contributor(s): Ciller, I M (author); Palanisamy, S K A (author); Ciller, Ursula A  (author); McFarlane, James R (author)orcid 
Publication Date: 2016
Handle Link: https://hdl.handle.net/1959.11/20231
Abstract: TGF-β superfamily members including bone morphogenetic proteins (BMPs) and their receptors (BMPR-1A, -1B and -2) have been shown to be important for reproductive function in both males and females, while information on the role of BMPs in males is limited. Functional studies on select BMPs and BMP receptors have demonstrated vital roles for these proteins in somatic and germ cell proliferation, steroidogenesis and overall fertility. In order to gain insight into the importance of these genes during postnatal reproductive development in males, our study was undertaken to specify the distribution of BMP and BMPR mRNA in male reproductive and steroidogenic tissues and quantify these genes in the testis using the mouse as our model. We screened testis at two, four, six and eight weeks of age for the expression of ten BMPs and three BMP receptors using RT-qPCR. All three BMP receptor mRNAs - Bmpr1a, Bmpr1b and Bmpr2, and ten BMP mRNAs - Bmp2, Bmp3, Bmp3b, Bmp4, Bmp5, Bmp6, Bmp7, Bmp8a, Bmp8b and Bmp15 were expressed in mouse testis at all stages screened. Testicular expression of genes varied within age groups and at specific developmental stages. Our study establishes an extensive BMP system in mouse reproductive and steroidogenic tissues.
Publication Type: Journal Article
Source of Publication: Physiological Research, 65(4), p. 673-682
Publisher: Akademie Ved Ceske Republiky, Fyziologicky Ustav, Czech Academy of Sciences, Institute of Physiology
Place of Publication: Czech Republic
ISSN: 1802-9973
0862-8408
Fields of Research (FoR) 2008: 111404 Reproduction
110306 Endocrinology
060604 Comparative Physiology
Fields of Research (FoR) 2020: 321503 Reproduction
320208 Endocrinology
310912 Comparative physiology
Socio-Economic Objective (SEO) 2008: 970106 Expanding Knowledge in the Biological Sciences
920114 Reproductive System and Disorders
970111 Expanding Knowledge in the Medical and Health Sciences
Socio-Economic Objective (SEO) 2020: 280102 Expanding knowledge in the biological sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Publisher/associated links: http://www.biomed.cas.cz/physiolres/pdf/65/65_673.pdf
Appears in Collections:Journal Article
School of Science and Technology

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