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https://hdl.handle.net/1959.11/20231
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DC Field | Value | Language |
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dc.contributor.author | Ciller, I M | en |
dc.contributor.author | Palanisamy, S K A | en |
dc.contributor.author | Ciller, Ursula A | en |
dc.contributor.author | McFarlane, James R | en |
dc.date.accessioned | 2017-03-22T17:35:00Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Physiological Research, 65(4), p. 673-682 | en |
dc.identifier.issn | 1802-9973 | en |
dc.identifier.issn | 0862-8408 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/20231 | - |
dc.description.abstract | TGF-β superfamily members including bone morphogenetic proteins (BMPs) and their receptors (BMPR-1A, -1B and -2) have been shown to be important for reproductive function in both males and females, while information on the role of BMPs in males is limited. Functional studies on select BMPs and BMP receptors have demonstrated vital roles for these proteins in somatic and germ cell proliferation, steroidogenesis and overall fertility. In order to gain insight into the importance of these genes during postnatal reproductive development in males, our study was undertaken to specify the distribution of BMP and BMPR mRNA in male reproductive and steroidogenic tissues and quantify these genes in the testis using the mouse as our model. We screened testis at two, four, six and eight weeks of age for the expression of ten BMPs and three BMP receptors using RT-qPCR. All three BMP receptor mRNAs - Bmpr1a, Bmpr1b and Bmpr2, and ten BMP mRNAs - Bmp2, Bmp3, Bmp3b, Bmp4, Bmp5, Bmp6, Bmp7, Bmp8a, Bmp8b and Bmp15 were expressed in mouse testis at all stages screened. Testicular expression of genes varied within age groups and at specific developmental stages. Our study establishes an extensive BMP system in mouse reproductive and steroidogenic tissues. | en |
dc.language | en | en |
dc.publisher | Akademie Ved Ceske Republiky, Fyziologicky Ustav, Czech Academy of Sciences, Institute of Physiology | en |
dc.relation.ispartof | Physiological Research | en |
dc.title | Postnatal Expression of Bone Morphogenetic Proteins and Their Receptors in the Mouse Testis | en |
dc.type | Journal Article | en |
dc.subject.keywords | Reproduction | en |
dc.subject.keywords | Comparative Physiology | en |
dc.subject.keywords | Endocrinology | en |
local.contributor.firstname | I M | en |
local.contributor.firstname | S K A | en |
local.contributor.firstname | Ursula A | en |
local.contributor.firstname | James R | en |
local.subject.for2008 | 111404 Reproduction | en |
local.subject.for2008 | 110306 Endocrinology | en |
local.subject.for2008 | 060604 Comparative Physiology | en |
local.subject.seo2008 | 970106 Expanding Knowledge in the Biological Sciences | en |
local.subject.seo2008 | 920114 Reproductive System and Disorders | en |
local.subject.seo2008 | 970111 Expanding Knowledge in the Medical and Health Sciences | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | School of Sci and Tech - Biomedical Science | en |
local.profile.email | uciller2@une.edu.au | en |
local.profile.email | jmcfarla@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-chute-20170321-095854 | en |
local.publisher.place | Czech Republic | en |
local.format.startpage | 673 | en |
local.format.endpage | 682 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 65 | en |
local.identifier.issue | 4 | en |
local.contributor.lastname | Ciller | en |
local.contributor.lastname | Palanisamy | en |
local.contributor.lastname | Ciller | en |
local.contributor.lastname | McFarlane | en |
dc.identifier.staff | une-id:uciller2 | en |
dc.identifier.staff | une-id:jmcfarla | en |
local.profile.orcid | 0000-0003-4429-5384 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:20429 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Postnatal Expression of Bone Morphogenetic Proteins and Their Receptors in the Mouse Testis | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.relation.url | http://www.biomed.cas.cz/physiolres/pdf/65/65_673.pdf | en |
local.search.author | Ciller, I M | en |
local.search.author | Palanisamy, S K A | en |
local.search.author | Ciller, Ursula A | en |
local.search.author | McFarlane, James R | en |
local.uneassociation | Unknown | en |
local.year.published | 2016 | en |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/4c65dc28-b5f3-4222-8dc2-c4bf929d5fce | en |
local.subject.for2020 | 321503 Reproduction | en |
local.subject.for2020 | 320208 Endocrinology | en |
local.subject.for2020 | 310912 Comparative physiology | en |
local.subject.seo2020 | 280102 Expanding knowledge in the biological sciences | en |
Appears in Collections: | Journal Article School of Science and Technology |
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