Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/60527
Title: Transdisciplinary implications from contemporary Australian natural product discoveries: Essential oils and saponins in phytochemistry, ethnopharmacology, and systematics
Contributor(s): Sadgrove, N J  (author); Telford, I R H  (author); Lyddiard, D  (author)orcid ; Collins, T L  (author); Klepp, J  (author); Legendre, S V A M  (author); Bruhl, J J  (author)orcid ; Jones, G L  (author)orcid ; Greatrex, B W  (author)orcid ; Van Wyk, B E (author)
Publication Date: 2016-12-14
DOI: 10.1055/s-0036-1597073
Handle Link: https://hdl.handle.net/1959.11/60527
Abstract: 

Over the last few years, in the course of natural product isolation, our research has enjoyed a 'cross-pollination' of chemistry, taxonomic botany, microbiology, pharmacology and ethnobotany. This search for interesting new metabolites from Australian members of Cupressaceae, Lamiaceae, Pittosporaceae, Rutaceae and Scrophulariaceae has generated a number of taxonomic queries leading to redeterminations and revision of species complexes (completed or underway). Also, phytochemical and ethnobotanical studies have discovered unique pleasant essential oils and therapeutic products respectively, which are now being focused on in the development of indigenous owned cottage industries that provide new fragrances and a treatment for atopic dermatitis (eczema) that utilises pittangretoside saponins and a traditional therapy of Aboriginal Australians [1]. Specific examples include: the genera Phebalium (Rutaceae) and Prostanthera (Lamiaceae), which yield secondary metabolites (sesquiterpenes and coumarins) correlating with morphological traits in heterogeneous species aggregates requiring revision; the two species Eremophila mitchellii (Scrophulariaceae) and E. sturtii have a history of being incorrectly determined and now we know that previous phytochemical studies [2, 3] reported novel metabolites from the wrong taxa; ethnobotanical and phytochemical studies in Eremophila have demonstrated several new natural products (genifuranal [4], myodesert-1-ene and others not yet named), some of which have significant antimicrobial or insecticidal activities; the isolation of the active components from a crude extract of Callitris glaucophylla (Cupressaceae) which inhibited methicillin resistant Staphylococcus aureus below 50 µg/ml; lastly, the development of a HPLC quantitation protocol for pittangretosides A – I [1] from aqueous extracts from Pittosporum angustifolium (Pittosporaceae) and the progress of negotiations with indigenous intellectual property rights owners.

Publication Type: Conference Publication
Conference Details: 9th Joint Natural Products Conference, Copenhagen, Denmark, 24th – 27th July, 2016
Source of Publication: Planta Medica, 82(S 01), p. S1-S381
Publisher: Georg Thieme Verlag
Place of Publication: Germany
ISSN: 1439-0221
0032-0943
Fields of Research (FoR) 2020: 310411 Plant and fungus systematics and taxonomy
HERDC Category Description: E3 Extract of Scholarly Conference Publication
Appears in Collections:Conference Publication
School of Environmental and Rural Science
School of Rural Medicine
School of Science and Technology

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