Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/9265
Title: | Novel endoperoxides: Synthesis and activity against 'Candida' species | Contributor(s): | Macreadie, Peter (author); Avery, Thomas D (author); Greatrex, Ben (author) ; Taylor, Dennis K (author); Macreadie, Ian G (author) | Publication Date: | 2006 | DOI: | 10.1016/j.bmcl.2005.10.101 | Handle Link: | https://hdl.handle.net/1959.11/9265 | Abstract: | Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic 'Candida' species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against 'Candida' growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents. | Publication Type: | Journal Article | Source of Publication: | Bioorganic & Medicinal Chemistry Letters, 16(4), p. 920-922 | Publisher: | Pergamon Press | Place of Publication: | United Kingdom | ISSN: | 1464-3405 0960-894X |
Fields of Research (FoR) 2008: | 030401 Biologically Active Molecules 030503 Organic Chemical Synthesis |
Socio-Economic Objective (SEO) 2008: | 970103 Expanding Knowledge in the Chemical Sciences 970106 Expanding Knowledge in the Biological Sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Rural Medicine |
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