Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/61782
Title: The impact of dietary protein on reproductive performance in rodents (Rats and mice)
Contributor(s): Ajuogu, Peter  (creator); McFarlane, James  (supervisor)orcid ; Hart, Robert  (supervisor)orcid ; Smart, Neil  (supervisor)orcid 
Publication Date: 2019
Open Access: Yes
DOI: 10.25952/cr8n-r672Open Access Link
Handle Link: https://hdl.handle.net/1959.11/61782
Related Research Outputs: https://hdl.handle.net/1959.11/57296
Abstract/Context: Maternal adaptation to pregnancy begins with the periconceptional period including ovulation, fertilization, implantation and early embryonic growth, and this stage is sensitive to nutritional perturbations, which consequently impacts on the postnatal adult health. In this study we investigated the effects of feeding a high and low protein diet over an 8 week period on plasma biochemistry and reproductive performance in mice. Adult virgin fertile female (n=60), were randomly distributed equally to three experimental groups, according to their diets, which contained different dietary protein levels; low (8%); high protein (35%) or adequate protein diet (control, 22%) for 6 weeks before mating and until day 10 of pregnancy. Body weights were not different between groups, but the conception rate for the low protein group was significantly lower than either the control or high protein groups. In those animals that did become pregnant embryo numbers were significantly lower in the low protein group compared to the control and high protein groups. Blood urea nitrogen and glucose were significantly lower and cholesterol higher in the low protein group. These results suggest diets low in protein have a significant negative impact on fertility.
Publication Type: Dataset
Fields of Research (FOR): 060603 Animal Physiology - Systems
111103 Nutritional Physiology
110306 Endocrinology
Fields of Research (FoR) 2020: 310910 Animal physiology - systems
320208 Endocrinology
Socio-Economic Objective (SEO): 830310 Sheep - Meat
920106 Endocrine Organs and Diseases (excl. Diabetes)
920114 Reproductive System and Disorders
Socio-Economic Objective (SEO) 2020: 100412 Sheep for meat
Keywords: reproductive organ weight
reproductive performance
plasma biochemistry
HERDC Category Description: X Dataset
Project: The impact of protein diet on reproductive performance in mice
Dataset Stored at: University of New England
Primary Contact Details: Peter K Ajuogu - peter.ajuogu@uniport.edu.ng
Dataset Custodian Details: James R McFarlane - jmcfarl9@une.edu.au
Appears in Collections:Dataset

Files in This Item:
4 files
File Description SizeFormat 
opendataset/Reproductive Parameters.xlsxDataset14.1 kBMicrosoft Excel XMLView/Open
opendataset/Peter PhD (Metabolites raw data)- 1st trial.csvDataset1.2 kBUnknownView/Open
opendataset/Peter PhD (Metabolites raw data) 2nd trial.csvDataset1.23 kBUnknownView/Open
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