Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/9364
Title: | Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis | Contributor(s): | Abu-Asab, Mones (author); Zhang, Ming (author); Amini, Dennis (author); Abu-Asab, Nihad (author); Amri, Hakima (author) | Publication Date: | 2011 | Open Access: | Yes | DOI: | 10.1155/2011/719059 | Handle Link: | https://hdl.handle.net/1959.11/9364 | Abstract: | Endometriosis is a multifactorial disease with poorly understood etiology, and reflecting an evolutionary nature where genetic alterations accumulate throughout pathogenesis. Our objective was to characterize the heterogeneous pathological process using parsimony phylogenetics. Gene expression microarray data of ovarian endometriosis obtained from NCBI database were polarized and coded into derived (abnormal) and ancestral (normal) states. Such alterations are referred to as synapomorphies in a phylogenetic sense (or biomarkers). Subsequent gene linkage was modeled by Genomatix BiblioSphere Pathway software. A list of clonally shared derived (abnormal) expressions revealed the pattern of heterogeneity among specimens. In addition, it has identified disruptions within the major regulatory pathways including those involved in cell proliferation, steroidogenesis, angiogenesis, cytoskeletal organization and integrity, and tumorigenesis, as well as cell adhesion and migration. Furthermore, the analysis supported the potential central involvement of ESR2 in the initiation of endometriosis. The pathogenesis mapping showed that eutopic and ectopic lesions have different molecular biosignatures. | Publication Type: | Journal Article | Source of Publication: | Obstetrics and Gynecology International, v.2011, p. 1-12 | Publisher: | Hindawi Publishing Corporation | Place of Publication: | United States of America | ISSN: | 1687-9597 1687-9589 |
Fields of Research (FoR) 2008: | 111404 Reproduction | Socio-Economic Objective (SEO) 2008: | 920114 Reproductive System and Disorders | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Rural Medicine |
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