Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/8710
Title: Small Angle X-Ray Scattering Signatures for Breast Cancer Detection: Direct Comparison of Synchrotron and Laboratory X-Ray Sources
Contributor(s): Siu, KKW (author); Sidhu, S (author); Falzon, Gregory  (author)orcid ; Nazaretian, S (author); Hart, SA (author); Fox, JG (author); Lewis, RA (author)
Publication Date: 2009
DOI: 10.1007/978-3-642-03879-2_170
Handle Link: https://hdl.handle.net/1959.11/8710
Abstract: Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.
Publication Type: Conference Publication
Conference Name: WC 2009: World Congress on Medical Physics and Biomedical Engineering - For the Benefit of the Patient, Munich, Germany, 7th - 12th September, 2009
Conference Details: WC 2009: World Congress on Medical Physics and Biomedical Engineering - For the Benefit of the Patient, Munich, Germany, 7th - 12th September, 2009
Source of Publication: IFMBE Proceedings, 25(II: Diagnostic Imaging), p. 607-610
Publisher: International Federation for Medical and Biological Engineering (IFMBE)
Place of Publication: Berlin, Germany
ISSN: 1680-0737
Field of Research (FOR): 111202 Cancer Diagnosis
029903 Medical Physics
Socio-Economic Outcome Codes: 920102 Cancer and Related Disorders
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
Other Links: http://trove.nla.gov.au/work/37889433
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Appears in Collections:Conference Publication
School of Science and Technology

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