Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/29522
Title: | Profilin: many facets of a small protein | Contributor(s): | Davey, Rhonda J (author); Moens, Pierre D J (author)![]() |
Publication Date: | 2020-08 | Early Online Version: | 2020-07-13 | DOI: | 10.1007/s12551-020-00723-3 | Handle Link: | https://hdl.handle.net/1959.11/29522 | Abstract: | Profilin is a ubiquitously expressed protein well known as a key regulator of actin polymerisation. The actin cytoskeleton is involved in almost all cellular processes including motility, endocytosis, metabolism, signal transduction and gene transcription. Hence, profilin’s role in the cell goes beyond its direct and essential function in regulating actin dynamics. This review will focus on the interactions of Profilin 1 and its ligands at the plasma membrane, in the cytoplasm and the nucleus of the cells and the regulation of profilin activity within those cell compartments. We will discuss the interactions of profilin in cell signalling pathways and highlight the importance of the cell context in the multiple functions that this small essential protein has in conjunction with its role in cytoskeletal organisation and dynamics. We will review some of the mechanisms that control profilin expression and the implications of changed expression of profilin in the light of cancer biology and other pathologies. | Publication Type: | Journal Article | Source of Publication: | Biophysical Reviews, 12(4), p. 827-849 | Publisher: | Springer | Place of Publication: | Germany | ISSN: | 1867-2469 1867-2450 |
Fields of Research (FoR) 2008: | 060103 Cell Development, Proliferation and Death 060199 Biochemistry and Cell Biology not elsewhere classified |
Fields of Research (FoR) 2020: | 310102 Cell development, proliferation and death | Socio-Economic Objective (SEO) 2008: | 920102 Cancer and Related Disorders 970111 Expanding Knowledge in the Medical and Health Sciences |
Socio-Economic Objective (SEO) 2020: | 280114 Expanding knowledge in Indigenous studies 280103 Expanding knowledge in the biomedical and clinical science 280112 Expanding knowledge in the health sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Science and Technology |
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