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https://hdl.handle.net/1959.11/29521| Title: | Cofilin and profilin: partners in cancer aggressiveness | Contributor(s): | Coumans, Joelle V F (author) ; Davey, Rhonda J (author); Moens, Pierre D J (author) |
Publication Date: | 2018-10 | Early Online Version: | 2018-07-19 | DOI: | 10.1007/s12551-018-0445-0 | Handle Link: | https://hdl.handle.net/1959.11/29521 | Abstract: | This review covers aspects of cofilin and profilin regulations and their influence on actin polymerisation responsible for cell motility and metastasis. The regulation of their activity by phosphorylation and nitration, miRs, PI(4,5)P2 binding, pH, oxidative stress and post-translational modification is described. In this review, we have highlighted selected similarities, complementarities and differences between the two proteins and how their interplay affects actin filament dynamics. | Publication Type: | Journal Article | Source of Publication: | Biophysical Reviews, 10(5), p. 1323-1335 | Publisher: | Springer | Place of Publication: | Germany | ISSN: | 1867-2469 1867-2450 |
Fields of Research (FoR) 2008: | 060103 Cell Development, Proliferation and Death 111201 Cancer Cell Biology |
Fields of Research (FoR) 2020: | 310102 Cell development, proliferation and death 321101 Cancer cell biology |
Socio-Economic Objective (SEO) 2008: | 920102 Cancer and Related Disorders | Socio-Economic Objective (SEO) 2020: | 200101 Diagnosis of human diseases and conditions | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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| Appears in Collections: | Journal Article School of Rural Medicine School of Science and Technology |
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