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https://hdl.handle.net/1959.11/20595| Title: | Effect of O-glycosylation and tyrosinesulfation of leech-derived peptides on binding and inhibitory activity against thrombin | Contributor(s): | Hsieh, Yves S Y (author); Taleski, Deni (author); Wilkinson, Brendan (author) ; Wijeyewickrema, Lakshmi C (author); Adams, Ty E (author); Pike, Robert N (author); Payne, Richard J (author) |
Publication Date: | 2012 | DOI: | 10.1039/c1cc14773k | Handle Link: | https://hdl.handle.net/1959.11/20595 | Abstract: | Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech 'Hirudinaria manillensis') is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage. | Publication Type: | Journal Article | Source of Publication: | Chemical Communications, 48(10), p. 1547-1549 | Publisher: | Royal Society of Chemistry | Place of Publication: | United Kingdom | ISSN: | 1364-548X 1359-7345 |
Fields of Research (FoR) 2008: | 030406 Proteins and Peptides 030503 Organic Chemical Synthesis 030401 Biologically Active Molecules |
Fields of Research (FoR) 2020: | 340503 Organic chemical synthesis 340407 Proteins and peptides 340401 Biologically active molecules |
Socio-Economic Objective (SEO) 2008: | 929999 Health not elsewhere classified 970103 Expanding Knowledge in the Chemical Sciences 970106 Expanding Knowledge in the Biological Sciences |
Socio-Economic Objective (SEO) 2020: | 280105 Expanding knowledge in the chemical sciences 280102 Expanding knowledge in the biological sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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| Appears in Collections: | Journal Article School of Science and Technology |
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