Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20595
Title: Effect of O-glycosylation and tyrosinesulfation of leech-derived peptides on binding and inhibitory activity against thrombin
Contributor(s): Hsieh, Yves S Y (author); Taleski, Deni (author); Wilkinson, Brendan (author)orcid ; Wijeyewickrema, Lakshmi C (author); Adams, Ty E (author); Pike, Robert N (author); Payne, Richard J (author)
Publication Date: 2012
DOI: 10.1039/c1cc14773k
Handle Link: https://hdl.handle.net/1959.11/20595
Abstract: Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech 'Hirudinaria manillensis') is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.
Publication Type: Journal Article
Source of Publication: Chemical Communications, 48(10), p. 1547-1549
Publisher: Royal Society of Chemistry
Place of Publication: United Kingdom
ISSN: 1364-548X
1359-7345
Field of Research (FOR): 030406 Proteins and Peptides
030503 Organic Chemical Synthesis
030401 Biologically Active Molecules
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
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