Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20008
Title: Photoswitchable carbohydrate-based fluorosurfactants as tuneable ice recrystallization inhibitors
Contributor(s): Adam, Madeleine K (author); Hu, Yingxue (author); Poisson, Jessica S (author); Pottage, Matthew J (author); Ben, Robert N (author); Wilkinson, Brendan  (author)orcid 
Publication Date: 2017
DOI: 10.1016/j.carres.2016.12.004
Handle Link: https://hdl.handle.net/1959.11/20008
Abstract: Cryopreservation is an important technique employed for the storage and preservation of biological tissues and cells. The limited effectiveness and significant toxicity of conventionally-used cryoprotectants, such as DMSO, have prompted efforts toward the rational design of less toxic alternatives, including carbohydrate-based surfactants. In this paper, we report the modular synthesis and ice recrystallization inhibition (IRI) activity of a library of variably substituted, carbohydrate-based fluorosurfactants. Carbohydrate-based fluorosurfactants possessed a variable mono- or disaccharide head group appended to a hydrophobic fluoroalkyl-substituted azobenzene tail group. Light-addressable fluorosurfactants displayed weak-to-moderate IRI activity that could be tuned through selection of carbohydrate head group, position of the trifluoroalkyl group on the azobenzene ring, and isomeric state of the azobenzene tail fragment.
Publication Type: Journal Article
Grant Details: ARC/DE130101673
Source of Publication: Carbohydrate Research, v.439, p. 1-8
Publisher: Pergamon Press
Place of Publication: United Kingdom
ISSN: 0008-6215
1873-426X
Field of Research (FOR): 030401 Biologically Active Molecules
030306 Synthesis of Materials
030503 Organic Chemical Synthesis
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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