Please use this identifier to cite or link to this item:
Title: Photoswitchable carbohydrate-based fluorosurfactants as tuneable ice recrystallization inhibitors
Contributor(s): Adam, Madeleine K (author); Hu, Yingxue (author); Poisson, Jessica S (author); Pottage, Matthew J (author); Ben, Robert N (author); Wilkinson, Brendan  (author)orcid 
Publication Date: 2017
DOI: 10.1016/j.carres.2016.12.004
Handle Link:
Abstract: Cryopreservation is an important technique employed for the storage and preservation of biological tissues and cells. The limited effectiveness and significant toxicity of conventionally-used cryoprotectants, such as DMSO, have prompted efforts toward the rational design of less toxic alternatives, including carbohydrate-based surfactants. In this paper, we report the modular synthesis and ice recrystallization inhibition (IRI) activity of a library of variably substituted, carbohydrate-based fluorosurfactants. Carbohydrate-based fluorosurfactants possessed a variable mono- or disaccharide head group appended to a hydrophobic fluoroalkyl-substituted azobenzene tail group. Light-addressable fluorosurfactants displayed weak-to-moderate IRI activity that could be tuned through selection of carbohydrate head group, position of the trifluoroalkyl group on the azobenzene ring, and isomeric state of the azobenzene tail fragment.
Publication Type: Journal Article
Grant Details: ARC/DE130101673
Source of Publication: Carbohydrate Research, v.439, p. 1-8
Publisher: Pergamon Press
Place of Publication: United Kingdom
ISSN: 0008-6215
Field of Research (FOR): 030401 Biologically Active Molecules
030306 Synthesis of Materials
030503 Organic Chemical Synthesis
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Statistics to Oct 2018: Visitors: 44
Views: 214
Downloads: 0
Appears in Collections:Journal Article

Files in This Item:
2 files
File Description SizeFormat 
Show full item record


checked on Nov 26, 2018

Page view(s)

checked on Feb 7, 2019
Google Media

Google ScholarTM



Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.