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We study (0,2) deformations of a (2,2) supersymmetric gauged linear sigma model for a Calabi-Yau hypersurface in a Fano toric variety. In the non-linear sigma model these correspond to some of the holomorphic deformations of the tangent bundle on the hypersurface. Combinatorial formulas are given for the number of these deformations, and we show that these numbers are exchanged by mirror symmetry in a subclass of the models.

Colorectal cancer (CRC) is the second leading cause of cancer associated deaths in developed countries. Cancer progression and metastatic spread is reliant on new blood vasculature, or angiogenesis. Tumour-related angiogenesis is regulated by proand anti-angiogenic factors secreted from malignant tissue in a stepwise process. Previously we structurally modified the small anti-angiogenic molecule quininib and discovered a more potent anti-angiogenic compound 1, 4 dihydroxy quininib (Q8), an antagonist of cysteinyl leukotriene receptor-1 with VEGF-independent bioactivity. Here, Q8, quininib (Q1) and five structural analogues were assayed for anti-tumorigenic effects in pre-clinical cancer models. Q8 reduced clone formation of the human colorectal cancer cell line HT29-Luc2. Gene silencing of CysLT1 in HT29-Luc2 cells significantly reduced expression of calpain-2. In human ex vivo colorectal cancer tumour explants, Q8 significantly decreased the secretion of both TIE-2 and VCAM-1 expression. In vivo Q8 was well tolerated up to 50 mg/kg by Balb/C mice and significantly more effective at reducing tumour volume in colorectal tumour xenografts compared to the parent drug quininib. In tumour xenografts, Q8 significantly reduced expression of the angiogenic marker calpain-2. In summary, we propose Q8 may act on the TIE-2-Angiopoietin signalling pathway to significantly inhibit the process of tumour angiogenesis in colorectal cancer.

In order for video replay to be an effective assessment and teaching tool, a number of steps need to be followed. This article provides some useful tips for physical educators to ensure they are implementing this video technology effectively when teaching the overarm throw.

Intervention in issues related to climate change is becoming a defined area of practice for clinical psychologists, with general competencies and a potential for specialization. Our chapter is a collaboration among several psychologists engaged in climate and environment-related research and practice. We synthesize findings and practices from climate science, environmental psychology, environmental justice, psychotherapy, health psychology, and international perspectives. The field of clinical psychology is primed to respond to the climate crisis by creatively applying knowledge of mental health and functioning and the delivery of just, culturally appropriate, and empirically supported treatments and therapies.

'12 THREADS' was a performance event of three newly developed and commissioned Australian art songs which presented contemporary stories, perspectives and thoughts from diverse Australian female artists.

12 THREADS utilised an innovative curatorial technique where 12 artists from diverse disciplines were brought together to collaborate on three new musical and vocal works. The project moved against the dominant composition process where the composer is seen as the central author of new music. In this project, vocalists, instrumentalists, writers, and composers were all equal contributors to the scope, focus, themes, and final aesthetic of the songs. Initial workshops encouraged collaboration and cross-disciplinary knowledge. The project drew on three types of writer, with the musicians collaborating across forms including poetry, prose fiction, and playwriting. The performances were all pairs of one singer and one instrumentalist and the work contributes to the Australia repertoire for cello, flute and recorder.

Background:The Boran (Bos indicus), indigenous Zebu cattle breed from subSaharan Africa, is remarkably well adapted to harsh tropical environments. Due to financial constraints and low-quality forage, African livestock are rarely fed at 100% maintenance energy requirements (MER) and the effect of sub-optimal restricted feeding on the rumen microbiome of African Zebu cattle remains largely unexplored. We collected 24 rumen fluid samples from six Boran cattle fed at suboptimal and optimal MER levels and characterised their rumen microbial composition by performing shotgun metagenomics and de novo assembly of metagenome-assembled genomes (MAGs). These MAGs were used as reference database to investigate the effect of diet restriction on the composition and functional potential of the rumen microbiome of African cattle.

Results: We report 1200 newly discovered MAGs from the rumen of Boran cattle. A total of 850 were dereplicated, and their uniqueness confirmed with pairwise comparisons (based on Mash distances) between African MAGs and other publicly available genomes from the rumen. A genome-centric investigation into sub-optimal diets highlighted a statistically significant effect on rumen microbial abundance profiles and a previously unobserved relationship between whole microbiome shifts in functional potential and taxon-level associations in metabolic pathways.

Conclusions: This study is the first to identify 1200 high-quality African rumen specific MAGs and provides further insight into the rumen function in harsh environments with food scarcity. The genomic information from the rumen microbiome of an indigenous African cattle breed sheds light on the microbiome contribution to rumen functionality and constitutes a vital resource in addressing food security in developing countries.

The 19th National Congress of the Chinese Communist Party - an event that happens only every five years - begins on 18 October. China's leadership will be selected at the five-day event, which will be attended by 2287 delegates from around China. The Asia Media Centre spoke to Xiang Gao (Lecturer at Eastern Institute of Technology, Auckland) about the biggest issues.

Many believe that data mining poses the biggest privacy challenge in the next decade. In this paper we concentrate on threats to privacy arising from the possibility of combining aggregate data to deduce the confidential individual values. We determine the maximum number of sum totals that can be disclosed without leading to a 2-compromise in a 1-dimensional database for range queries.

Many believe that data mining poses the biggest privacy challenge in the next decade. In this paper we concentrate on threats to privacy arising from the possibility of combining aggregate data to deduce the confidential individual values. We determine the maximum number of sum totals that can be disclosed without leading to a 2-compromise in a 1-dimensional database for range queries.