Adam, Madeleine K

Jarrett-Wilkins, Charles

Ben, Robert N

Wilkinson, Brendan

Beards, Michael

Staykov, Emiliyan

MacFarlane, Liam R

Bell, Toby D M

Matthews, Jacqueline M

Manners, Ian

Faul, Charl F J

Moens, Pierre

2018

Antifreeze glycoproteins (AFGPs) are polymeric natural products that have drawn considerable interest in diverse research fields owing to their potent ice recrystallization inhibition (IRI) activity. Self-assembled materials have emerged as a promising class of biomimetic ice growth inhibitor, yet the development of AFGP-based supramolecular materials that emulate the aggregative behavior of AFGPs have not yet been reported. Here, we demonstrate the first example of the 1D self-assembly and IRI activity of AFGP-functionalized perylene bisimides (AFGP-PBIs). Glycopeptide-functionalized PBIs underwent 1D self-assembly in water and showed modest IRI activity, which could be tuned through substitution of the PBI core. This work presents essential proof-of-principle for the development of novel IRIs as potential supramolecular cryoprotectans and glycoprotein mimics.

Chemistry: A European Journal, 24(31), p. 7834-7839

1521-3765

0947-6539

https://hdl.handle.net/1959.11/23322

en

Wiley-VCH Verlag GmbH & Co KGaA

1D Self-Assembly and Ice Recrystallization Inhibition Activity of Antifreeze Glycopeptide-Functionalized Perylene Bisimides

Journal Article

Publication