Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/63887
Title: Expression of Immune Genes and Leukocyte Population in the Conjunctiva, Harderian Gland and Trachea of Chickens Inoculated with a Live Vaccine and a Field Strain Infectious Laryngotracheitis Virus
Contributor(s): Tran, Thanh Tien (author); Andronicos, Nicholas  (author)orcid ; Gerber, Priscilla F  (author)orcid 
Publication Date: 2024-12
Open Access: Yes
DOI: 10.3390/poultry3040030
Handle Link: https://hdl.handle.net/1959.11/63887
Abstract: 

Changes in leukocyte populations and immune gene expression associated with attenuated vaccine (SA2) or field (Class 9) strains of infectious laryngotracheitis virus in chicken pullets were observed primarily in the trachea and conjunctiva, while no substantial changes were detected in the Harderian gland. Although there were no significant differences in cellular infiltration in the tissues exposed to Class 9 and SA2, Class 9 induced greater changes in immune gene expression than SA2 in the trachea and conjunctiva and significantly upregulated CD4, CD8A, IRF1, STAT4 and downregulated CXCL12 expression in the trachea. Meanwhile, SA2 significantly upregulated CD14 and downregulated MPO, CCR6 and RAG1 expression in the conjunctiva. In conclusion, gene expression in pullets infected with SA2 and Class 9 were mostly related to inflammatory and tissue-repairing responses in the trachea and conjunctiva. Compared to SA2, Class 9 inoculation was associated with a more robust gene expression of immune markers" however, a larger infiltration of Kul01+, Bu1+ and CD8a+ cells was observed in trachea and conjunctiva after SA2 inoculation.

Publication Type: Journal Article
Grant Details: ARC/DE200101832
Source of Publication: Poultry, 3(4), p. 399-408
Publisher: MDPI AG
Place of Publication: Switzerland
ISSN: 2674-1164
Fields of Research (FoR) 2020: 3009 Veterinary sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Environmental and Rural Science
School of Science and Technology

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