Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/56329
Title: Levoglucosenone: Bio-Based Platform for Drug Discovery
Contributor(s): Camp, Jason E (author); Greatrex, Ben W  (author)orcid 
Publication Date: 2022-05-31
Open Access: Yes
DOI: 10.3389/fchem.2022.902239
Handle Link: https://hdl.handle.net/1959.11/56329
Abstract: 

Levoglucosone (LGO) is a bio-privileged molecule that can be produced on scale from waste biomass. This chiral building block has been converted via well-established chemical processes into previously difficult-to-synthesize building blocks such as enantiopure butenolides, dihydropyrans, substituted cyclopropanes, deoxy-sugars and ribonolactones. LGO is an excellent starting material for the synthesis of biologically active compounds, including those which have anti-cancer, anti-microbial or anti-inflammatory activity. This review will cover the conversion of LGO to biologically active compounds as well as provide future research directions related to this platform molecule.

Publication Type: Journal Article
Source of Publication: Frontiers in Chemistry, v.10, p. 1-9
Publisher: Frontiers Research Foundation
Place of Publication: Switzerland
ISSN: 2296-2646
Fields of Research (FoR) 2020: 340503 Organic chemical synthesis
340504 Organic green chemistry
340502 Natural products and bioactive compounds
Socio-Economic Objective (SEO) 2020: 280105 Expanding knowledge in the chemical sciences
240803 Human pharmaceutical treatments
170701 Biomass processing
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Rural Medicine

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