Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/48545
Title: Identification of defective early immune responses to Burkholderia pseudomallei infection in a diet-induced murine model of type 2 diabetes
Contributor(s): Morris, Jodie L (author); Govan, Brenda L (author); Rush, Catherine M (author); Ketheesan, Natkunam  (author)orcid 
Publication Date: 2021-06
Early Online Version: 2021-02-08
DOI: 10.1016/j.micinf.2021.104793
Handle Link: https://hdl.handle.net/1959.11/48545
Abstract: 

Co-occurrence of bacterial infections with type 2 diabetes (T2D) is a global problem. Melioidosis caused by Burkholderia pseudomallei is 10 times more likely to occur in patients with T2D, than in normoglycemic individuals. Using an experimental model of T2D, we observed that greater susceptibility in T2D was due to differences in proportions of infiltrating leucocytes and reduced levels of MCP-1, IFN-γ and IL-12 at sites of infection within 24 h post-infection. However, by 72 h the levels of inflammatory cytokines and bacteria were markedly higher in visceral tissue and blood in T2D mice. In T2D, dysregulated early immune responses are responsible for the greater predisposition to B. pseudomallei infection.

Publication Type: Journal Article
Source of Publication: Microbes and Infection, 23(4-5), p. 1-6
Publisher: Elsevier Masson
Place of Publication: France
ISSN: 1769-714X
1286-4579
Fields of Research (FoR) 2020: 320211 Infectious diseases
320701 Medical bacteriology
Socio-Economic Objective (SEO) 2020: 200104 Prevention of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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