1. Research UNE
  2. UNE
  3. Journal Article
Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/48545
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMorris, Jodie Len
dc.contributor.authorGovan, Brenda Len
dc.contributor.authorRush, Catherine Men
dc.contributor.authorKetheesan, Natkunamen
dc.date.accessioned2022-03-10T22:18:08Z-
dc.date.available2022-03-10T22:18:08Z-
dc.date.issued2021-06-
dc.identifier.citationMicrobes and Infection, 23(4-5), p. 1-6en
dc.identifier.issn1769-714Xen
dc.identifier.issn1286-4579en
dc.identifier.urihttps://hdl.handle.net/1959.11/48545-
dc.description.abstract<p>Co-occurrence of bacterial infections with type 2 diabetes (T2D) is a global problem. Melioidosis caused by <i>Burkholderia pseudomallei</i> is 10 times more likely to occur in patients with T2D, than in normoglycemic individuals. Using an experimental model of T2D, we observed that greater susceptibility in T2D was due to differences in proportions of infiltrating leucocytes and reduced levels of MCP-1, IFN-γ and IL-12 at sites of infection within 24 h post-infection. However, by 72 h the levels of inflammatory cytokines and bacteria were markedly higher in visceral tissue and blood in T2D mice. In T2D, dysregulated early immune responses are responsible for the greater predisposition to <i>B. pseudomallei</i> infection.en
dc.languageenen
dc.publisherElsevier Massonen
dc.relation.ispartofMicrobes and Infectionen
dc.titleIdentification of defective early immune responses to Burkholderia pseudomallei infection in a diet-induced murine model of type 2 diabetesen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.micinf.2021.104793en
dc.identifier.pmid33571673en
local.contributor.firstnameJodie Len
local.contributor.firstnameBrenda Len
local.contributor.firstnameCatherine Men
local.contributor.firstnameNatkunamen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailnkethees@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeFranceen
local.identifier.runningnumber104793en
local.format.startpage1en
local.format.endpage6en
local.identifier.scopusid85108375063en
local.peerreviewedYesen
local.identifier.volume23en
local.identifier.issue4-5en
local.contributor.lastnameMorrisen
local.contributor.lastnameGovanen
local.contributor.lastnameRushen
local.contributor.lastnameKetheesanen
dc.identifier.staffune-id:nketheesen
local.profile.orcid0000-0002-4870-706Xen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/48545en
local.date.onlineversion2021-02-08-
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleIdentification of defective early immune responses to Burkholderia pseudomallei infection in a diet-induced murine model of type 2 diabetesen
local.relation.fundingsourcenoteJames Cook Universityen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorMorris, Jodie Len
local.search.authorGovan, Brenda Len
local.search.authorRush, Catherine Men
local.search.authorKetheesan, Natkunamen
local.uneassociationYesen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.identifier.wosid000673636100005en
local.year.available2021en
local.year.published2021en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/d2793b88-0c1c-4035-8b64-91457e09aadcen
local.subject.for2020320211 Infectious diseasesen
local.subject.for2020320701 Medical bacteriologyen
local.subject.seo2020200104 Prevention of human diseases and conditionsen
Appears in Collections:Journal Article
School of Science and Technology
Files in This Item:
1 files
File SizeFormat 
Show simple item record

SCOPUSTM   
Citations

2
checked on Jan 4, 2025

Page view(s)

908
checked on Jun 18, 2023
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.