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https://hdl.handle.net/1959.11/3412
Title: | Determinants of Fetal Leptin Synthesis, Fat Mass, and Circulating Leptin Concentrations in Well-Nourished Ewes in Late Pregnancy | Contributor(s): | Mühlhäusler, B S (author); Roberts, C T (author); Yuen, B S J (author); Marrocco, E (author); Budge, H (author); Symonds, M E (author); McFarlane, J R (author) ; Kauter, K G (author); Stagg, P (author); Pearse, J K (author); McMillen, I C (author) | Publication Date: | 2003 | DOI: | 10.1210/en.2003-0555 | Handle Link: | https://hdl.handle.net/1959.11/3412 | Abstract: | We have investigated the factors regulating leptin synthesis, fat deposition, and circulating leptin concentrations in fetuses of well nourished ewes in late pregnancy. Vascular catheters were surgically inserted in 17 pregnant ewes and their fetuses at 103–120 d gestation (term = 147 ± 37). Ewes were fed a diet providing either 100% (control; n = 9) or approximately 155% (well fed; n = 8) of the maintenance energy requirements and fetal perirenal and interscapular fat depots were collected at 139–141 d gestation. There was a significant relationship between the relative mass of fetal unilocular fat and fetal glucose (relative mass of unilocular fat, 1.14; fetal glucose, +0.16; r = 0.50; P < 0.04; n = 17), but not insulin, concentrations in the control and well-fed groups. In contrast to the controls, there was a positive relationship between the relative abundance of leptin mRNA and fetal insulin, but not glucose, concentrations in fetal perirenal adipose tissue in the well-fed group. A moderate increase in maternal nutrition also resulted in a strong reciprocal relationship between uncoupling protein 1 and leptin expression in fetal perirenal adipose tissue in late gestation (well-fed group: uncoupling protein 1 mRNA:18S rRNA,-0.51; leptin mRNA:β-actin mRNA, +1.53; r = 0.80; P < 0.02; n = 8). These studies provide evidence that fetal glucose and insulin differentially regulate fetal fat deposition and leptin mRNA expression within the fetal perirenal fat depot in the well nourished animal during late gestation. | Publication Type: | Journal Article | Source of Publication: | Endocrinology, 144(11), p. 4947-4954 | Publisher: | Oxford University Press | Place of Publication: | United States of America | ISSN: | 1945-7170 0013-7227 |
Fields of Research (FoR) 2008: | 111404 Reproduction | Socio-Economic Objective (SEO) 2008: | 920114 Reproductive System and Disorders | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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