Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/31865
Title: Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position
Contributor(s): Heffernan, S M (author); Stebbings, G K (author); Kilduff, L P (author); Erskine, R M (author); Day, S H (author); Morse, C I (author); McPhee, J S (author); Cook, C J  (author)orcid ; Vance, B (author); Ribbans, W J (author); Raleigh, S M (author); Roberts, C (author); Bennet, M A (author); Wang, G (author); Collins, M (author); Pitsiladis, Y P (author); Williams, A G (author)
Publication Date: 2017
Early Online Version: 2017-01-17
Open Access: Yes
DOI: 10.1186/s12863-017-0470-1
Handle Link: https://hdl.handle.net/1959.11/31865
Abstract: 

Background:FTO gene variants have been associated with obesity phenotypes in sedentary and obese populations, but rarely with skeletal muscle and elite athlete phenotypes.
Methods: In 1089 participants, comprising 530 elite rugby athletes and 559 non-athletes, DNA was collected and genotyped for the FTO rs9939609 variant using real-time PCR. In a subgroup of non-resistance trained individuals (NT; n = 120), we also assessed structural and functional skeletal muscle phenotypes using dual energy x-ray absorptiometry, ultrasound and isokinetic dynamometry. In a subgroup of rugby athletes (n = 77), we assessed muscle power during a countermovement jump.
Results: In NT, TT genotype and T allele carriers had greater total body (4.8% and 4.1%) and total appendicular lean mass (LM; 3.0% and 2.1%) compared to AA genotype, with greater arm LM (0.8%) in T allele carriers and leg LM (2.1%) for TT, compared to AA genotype. Furthermore, the T allele was more common (94%) in selected elite rugby union athletes (back three and centre players) who are most reliant on LM rather than total body mass for success, compared to other rugby athletes (82%; P = 0.01, OR = 3.34) and controls (84%; P = 0.03, OR = 2.88). Accordingly, these athletes had greater peak power relative to body mass than other rugby athletes (14%; P = 2 x 10-6).
Conclusion: It appears that the C alleles, CC genotypes and resulting combinations of both rs12722 and rs3196378 are beneficial for rugby athletes to achieve elite status and carriage of these variants may impart an inherited resistance against soft tissue injury, despite exposure to the high-risk environment of elite rugby. These data have implications for the management of inter-individual differences in injury risk amongst elite athletes.

Publication Type: Journal Article
Source of Publication: BMC Genetics, v.18, p. 1-9
Publisher: BioMed Central Ltd
Place of Publication: United Kingdom
ISSN: 1471-2156
Fields of Research (FoR) 2020: 320803 Systems physiology
Socio-Economic Objective (SEO) 2020: 280103 Expanding knowledge in the biomedical and clinical sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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