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https://hdl.handle.net/1959.11/31865
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DC Field | Value | Language |
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dc.contributor.author | Heffernan, S M | en |
dc.contributor.author | Stebbings, G K | en |
dc.contributor.author | Kilduff, L P | en |
dc.contributor.author | Erskine, R M | en |
dc.contributor.author | Day, S H | en |
dc.contributor.author | Morse, C I | en |
dc.contributor.author | McPhee, J S | en |
dc.contributor.author | Cook, C J | en |
dc.contributor.author | Vance, B | en |
dc.contributor.author | Ribbans, W J | en |
dc.contributor.author | Raleigh, S M | en |
dc.contributor.author | Roberts, C | en |
dc.contributor.author | Bennet, M A | en |
dc.contributor.author | Wang, G | en |
dc.contributor.author | Collins, M | en |
dc.contributor.author | Pitsiladis, Y P | en |
dc.contributor.author | Williams, A G | en |
dc.date.accessioned | 2021-11-10T05:58:50Z | - |
dc.date.available | 2021-11-10T05:58:50Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | BMC Genetics, v.18, p. 1-9 | en |
dc.identifier.issn | 1471-2156 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/31865 | - |
dc.description.abstract | <p><b>Background:</b><i>FTO</i> gene variants have been associated with obesity phenotypes in sedentary and obese populations, but rarely with skeletal muscle and elite athlete phenotypes.<br/><b>Methods:</b> In 1089 participants, comprising 530 elite rugby athletes and 559 non-athletes, DNA was collected and genotyped for the <i>FTO</i> rs9939609 variant using real-time PCR. In a subgroup of non-resistance trained individuals (NT; <i>n</i> = 120), we also assessed structural and functional skeletal muscle phenotypes using dual energy x-ray absorptiometry, ultrasound and isokinetic dynamometry. In a subgroup of rugby athletes (<i>n</i> = 77), we assessed muscle power during a countermovement jump.<br/><b>Results:</b> In NT, TT genotype and T allele carriers had greater total body (4.8% and 4.1%) and total appendicular lean mass (LM; 3.0% and 2.1%) compared to AA genotype, with greater arm LM (0.8%) in T allele carriers and leg LM (2.1%) for TT, compared to AA genotype. Furthermore, the T allele was more common (94%) in selected elite rugby union athletes (back three and centre players) who are most reliant on LM rather than total body mass for success, compared to other rugby athletes (82%; <i>P</i> = 0.01, OR = 3.34) and controls (84%; <i>P</i> = 0.03, OR = 2.88). Accordingly, these athletes had greater peak power relative to body mass than other rugby athletes (14%; <i>P</i> = 2 x 10<sup>-6</sup>).<br/><b>Conclusion:</b> It appears that the C alleles, CC genotypes and resulting combinations of both rs12722 and rs3196378 are beneficial for rugby athletes to achieve elite status and carriage of these variants may impart an inherited resistance against soft tissue injury, despite exposure to the high-risk environment of elite rugby. These data have implications for the management of inter-individual differences in injury risk amongst elite athletes.</p> | en |
dc.language | en | en |
dc.publisher | BioMed Central Ltd | en |
dc.relation.ispartof | BMC Genetics | en |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1186/s12863-017-0470-1 | en |
dc.identifier.pmid | 28103813 | en |
dcterms.accessRights | UNE Green | en |
local.contributor.firstname | S M | en |
local.contributor.firstname | G K | en |
local.contributor.firstname | L P | en |
local.contributor.firstname | R M | en |
local.contributor.firstname | S H | en |
local.contributor.firstname | C I | en |
local.contributor.firstname | J S | en |
local.contributor.firstname | C J | en |
local.contributor.firstname | B | en |
local.contributor.firstname | W J | en |
local.contributor.firstname | S M | en |
local.contributor.firstname | C | en |
local.contributor.firstname | M A | en |
local.contributor.firstname | G | en |
local.contributor.firstname | M | en |
local.contributor.firstname | Y P | en |
local.contributor.firstname | A G | en |
local.profile.school | School of Science and Technology | en |
local.profile.email | ccook29@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United Kingdom | en |
local.identifier.runningnumber | 4 | en |
local.format.startpage | 1 | en |
local.format.endpage | 9 | en |
local.identifier.scopusid | 85009953616 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 18 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Heffernan | en |
local.contributor.lastname | Stebbings | en |
local.contributor.lastname | Kilduff | en |
local.contributor.lastname | Erskine | en |
local.contributor.lastname | Day | en |
local.contributor.lastname | Morse | en |
local.contributor.lastname | McPhee | en |
local.contributor.lastname | Cook | en |
local.contributor.lastname | Vance | en |
local.contributor.lastname | Ribbans | en |
local.contributor.lastname | Raleigh | en |
local.contributor.lastname | Roberts | en |
local.contributor.lastname | Bennet | en |
local.contributor.lastname | Wang | en |
local.contributor.lastname | Collins | en |
local.contributor.lastname | Pitsiladis | en |
local.contributor.lastname | Williams | en |
dc.identifier.staff | une-id:ccook29 | en |
local.profile.orcid | 0000-0001-9677-0306 | en |
local.profile.role | author | en |
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local.profile.role | author | en |
local.profile.role | author | en |
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local.profile.role | author | en |
local.profile.role | author | en |
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local.profile.role | author | en |
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local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/31865 | en |
local.date.onlineversion | 2017-01-17 | - |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position | en |
local.relation.fundingsourcenote | Manchester Metropolitan University | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Heffernan, S M | en |
local.search.author | Stebbings, G K | en |
local.search.author | Kilduff, L P | en |
local.search.author | Erskine, R M | en |
local.search.author | Day, S H | en |
local.search.author | Morse, C I | en |
local.search.author | McPhee, J S | en |
local.search.author | Cook, C J | en |
local.search.author | Vance, B | en |
local.search.author | Ribbans, W J | en |
local.search.author | Raleigh, S M | en |
local.search.author | Roberts, C | en |
local.search.author | Bennet, M A | en |
local.search.author | Wang, G | en |
local.search.author | Collins, M | en |
local.search.author | Pitsiladis, Y P | en |
local.search.author | Williams, A G | en |
local.open.fileurl | https://rune.une.edu.au/web/retrieve/ce04b2de-8338-4136-ac38-411322a5eaf2 | en |
local.uneassociation | No | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.identifier.wosid | 000392994000002 | en |
local.year.available | 2017 | en |
local.year.published | 2017 | en |
local.fileurl.open | https://rune.une.edu.au/web/retrieve/ce04b2de-8338-4136-ac38-411322a5eaf2 | en |
local.fileurl.openpublished | https://rune.une.edu.au/web/retrieve/ce04b2de-8338-4136-ac38-411322a5eaf2 | en |
local.subject.for2020 | 320803 Systems physiology | en |
local.subject.seo2020 | 280103 Expanding knowledge in the biomedical and clinical sciences | en |
local.codeupdate.date | 2021-11-10T17:04:40.425 | en |
local.codeupdate.eperson | ccook29@une.edu.au | en |
local.codeupdate.finalised | true | en |
local.original.for2020 | 320803 Systems physiology | en |
local.original.seo2020 | 280103 Expanding knowledge in the biomedical and clinical sciences | en |
Appears in Collections: | Journal Article School of Science and Technology |
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openpublished/FatMassCook2017JournalArticle.pdf | Published version | 567.03 kB | Adobe PDF Download Adobe | View/Open |
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