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https://hdl.handle.net/1959.11/30541
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DC Field | Value | Language |
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dc.contributor.author | Mueller, Maci L | en |
dc.contributor.author | Cole, John B | en |
dc.contributor.author | Connors, Natalie K | en |
dc.contributor.author | Johnston, David J | en |
dc.contributor.author | Randhawa, Imtiaz A S | en |
dc.contributor.author | Van Eenennaam, Alison L | en |
dc.date.accessioned | 2021-05-05T04:47:43Z | - |
dc.date.available | 2021-05-05T04:47:43Z | - |
dc.date.issued | 2021-02-11 | - |
dc.identifier.citation | Frontiers in Genetics, v.12, p. 1-23 | en |
dc.identifier.issn | 1664-8021 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/30541 | - |
dc.description.abstract | Dehorning is the process of physically removing horns to protect animals and humans from injury, but the process is costly, unpleasant, and faces increasing public scrutiny. Genetic selection for polled (hornless), which is genetically dominant to horned, is a long-term solution to eliminate the need for dehorning. However, due to the limited number of polled Australian Brahman bulls, the northern Australian beef cattle population remains predominantly horned. The potential to use gene editing to produce high-genetic-merit polled cattle was recently demonstrated. To further explore the concept, this study simulated introgression of the <i>POLLED</i> allele into a tropically adapted Australian beef cattle population via conventional breeding or gene editing (top 1% or 10% of seedstock bulls/year) for 3 polled mating schemes and compared results to baseline selection on genetic merit (Japan Ox selection index, $JapOx) alone, over the course of 20 years. The baseline scenario did not significantly decrease the 20-year <i>HORNED</i> allele frequency (80%), but resulted in one of the fastest rates of genetic gain ($8.00/year). Compared to the baseline, the conventional breeding scenarios where polled bulls were preferentially used for breeding, regardless of their genetic merit, significantly decreased the 20-year <i>HORNED</i> allele frequency (30%), but resulted in a significantly slower rate of genetic gain ($6.70/year, <i>P</i> ≤ 0.05). The mating scheme that required the exclusive use of homozygous polled bulls, resulted in the lowest 20-year <i>HORNED</i> allele frequency (8%), but this conventional breeding scenario resulted in the slowest rate of genetic gain ($5.50/year). The addition of gene editing the top 1% or 10% of seedstock bull calves/year to each conventional breeding scenario resulted in significantly faster rates of genetic gain (up to $8.10/year, <i>P</i> ≤ 0.05). Overall, our study demonstrates that, due to the limited number of polled Australian Brahman bulls, strong selection pressure on polled will be necessary to meaningfully increase the number of polled animals in this population. Moreover, these scenarios illustrate how gene editing could be a tool for accelerating the development of high-genetic-merit homozygous polled sires to mitigate the current trade-off of slower genetic gain associated with decreasing <i>HORNED</i> allele frequency in the Australian Brahman population. | en |
dc.language | en | en |
dc.publisher | Frontiers Research Foundation | en |
dc.relation.ispartof | Frontiers in Genetics | en |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Comparison of Gene Editing Versus Conventional Breeding to Introgress the POLLED Allele Into the Tropically Adapted Australian Beef Cattle Population | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.3389/fgene.2021.593154 | en |
dc.identifier.pmid | 33643378 | en |
dcterms.accessRights | UNE Green | en |
local.contributor.firstname | Maci L | en |
local.contributor.firstname | John B | en |
local.contributor.firstname | Natalie K | en |
local.contributor.firstname | David J | en |
local.contributor.firstname | Imtiaz A S | en |
local.contributor.firstname | Alison L | en |
local.subject.for2008 | 070201 Animal Breeding | en |
local.subject.seo2008 | 830301 Beef Cattle | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | Animal Genetics and Breeding Unit | en |
local.profile.email | nconnor2@une.edu.au | en |
local.profile.email | djohnsto@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | Switzerland | en |
local.identifier.runningnumber | 593154 | en |
local.format.startpage | 1 | en |
local.format.endpage | 23 | en |
local.identifier.scopusid | 85101674298 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 12 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Mueller | en |
local.contributor.lastname | Cole | en |
local.contributor.lastname | Connors | en |
local.contributor.lastname | Johnston | en |
local.contributor.lastname | Randhawa | en |
local.contributor.lastname | Van Eenennaam | en |
dc.identifier.staff | une-id:nconnor2 | en |
dc.identifier.staff | une-id:djohnsto | en |
local.profile.orcid | 0000-0003-4866-4757 | en |
local.profile.orcid | 0000-0002-4995-8311 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/30541 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Comparison of Gene Editing Versus Conventional Breeding to Introgress the POLLED Allele Into the Tropically Adapted Australian Beef Cattle Population | en |
local.relation.fundingsourcenote | This project was supported in part by funds from the USDA National Institute of Food and Agriculture National Research Initiative Competitive Grant no. 2015-67015-23316 (T. S. Sonstegard, PD), and a Henry A. Jastro graduate research award to MM. MM was supported by the National Institute for Food and Agriculture National Needs Graduate and Postgraduate Fellowship no. 2017-38420-26790 from the United States Department of Agriculture. JC was supported by appropriated project 8042-31000-002-00-D, “Improving Dairy Animals by Increasing Accuracy of Genomic Prediction, Evaluating New Traits, and Redefining Selection Goals,” of the Agricultural Research Service of the United States Department of Agriculture. | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Mueller, Maci L | en |
local.search.author | Cole, John B | en |
local.search.author | Connors, Natalie K | en |
local.search.author | Johnston, David J | en |
local.search.author | Randhawa, Imtiaz A S | en |
local.search.author | Van Eenennaam, Alison L | en |
local.open.fileurl | https://rune.une.edu.au/web/retrieve/3028e6f0-cb0b-41b5-9e13-ab718a9e57a2 | en |
local.uneassociation | Yes | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.identifier.wosid | 000621394300001 | en |
local.year.published | 2021 | en |
local.fileurl.open | https://rune.une.edu.au/web/retrieve/3028e6f0-cb0b-41b5-9e13-ab718a9e57a2 | en |
local.fileurl.openpublished | https://rune.une.edu.au/web/retrieve/3028e6f0-cb0b-41b5-9e13-ab718a9e57a2 | en |
local.subject.for2020 | 300305 Animal reproduction and breeding | en |
local.subject.seo2020 | 100401 Beef cattle | en |
Appears in Collections: | Animal Genetics and Breeding Unit (AGBU) Journal Article School of Science and Technology |
Files in This Item:
File | Description | Size | Format | |
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openpublished/ComparisonConnorsJohnston2021JournalArticle.pdf | Published version | 5.61 MB | Adobe PDF Download Adobe | View/Open |
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