Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/30541
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dc.contributor.authorMueller, Maci Len
dc.contributor.authorCole, John Ben
dc.contributor.authorConnors, Natalie Ken
dc.contributor.authorJohnston, David Jen
dc.contributor.authorRandhawa, Imtiaz A Sen
dc.contributor.authorVan Eenennaam, Alison Len
dc.date.accessioned2021-05-05T04:47:43Z-
dc.date.available2021-05-05T04:47:43Z-
dc.date.issued2021-02-11-
dc.identifier.citationFrontiers in Genetics, v.12, p. 1-23en
dc.identifier.issn1664-8021en
dc.identifier.urihttps://hdl.handle.net/1959.11/30541-
dc.description.abstractDehorning is the process of physically removing horns to protect animals and humans from injury, but the process is costly, unpleasant, and faces increasing public scrutiny. Genetic selection for polled (hornless), which is genetically dominant to horned, is a long-term solution to eliminate the need for dehorning. However, due to the limited number of polled Australian Brahman bulls, the northern Australian beef cattle population remains predominantly horned. The potential to use gene editing to produce high-genetic-merit polled cattle was recently demonstrated. To further explore the concept, this study simulated introgression of the <i>POLLED</i> allele into a tropically adapted Australian beef cattle population via conventional breeding or gene editing (top 1% or 10% of seedstock bulls/year) for 3 polled mating schemes and compared results to baseline selection on genetic merit (Japan Ox selection index, $JapOx) alone, over the course of 20 years. The baseline scenario did not significantly decrease the 20-year <i>HORNED</i> allele frequency (80%), but resulted in one of the fastest rates of genetic gain ($8.00/year). Compared to the baseline, the conventional breeding scenarios where polled bulls were preferentially used for breeding, regardless of their genetic merit, significantly decreased the 20-year <i>HORNED</i> allele frequency (30%), but resulted in a significantly slower rate of genetic gain ($6.70/year, <i>P</i> ≤ 0.05). The mating scheme that required the exclusive use of homozygous polled bulls, resulted in the lowest 20-year <i>HORNED</i> allele frequency (8%), but this conventional breeding scenario resulted in the slowest rate of genetic gain ($5.50/year). The addition of gene editing the top 1% or 10% of seedstock bull calves/year to each conventional breeding scenario resulted in significantly faster rates of genetic gain (up to $8.10/year, <i>P</i> ≤ 0.05). Overall, our study demonstrates that, due to the limited number of polled Australian Brahman bulls, strong selection pressure on polled will be necessary to meaningfully increase the number of polled animals in this population. Moreover, these scenarios illustrate how gene editing could be a tool for accelerating the development of high-genetic-merit homozygous polled sires to mitigate the current trade-off of slower genetic gain associated with decreasing <i>HORNED</i> allele frequency in the Australian Brahman population.en
dc.languageenen
dc.publisherFrontiers Research Foundationen
dc.relation.ispartofFrontiers in Geneticsen
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleComparison of Gene Editing Versus Conventional Breeding to Introgress the POLLED Allele Into the Tropically Adapted Australian Beef Cattle Populationen
dc.typeJournal Articleen
dc.identifier.doi10.3389/fgene.2021.593154en
dc.identifier.pmid33643378en
dcterms.accessRightsUNE Greenen
local.contributor.firstnameMaci Len
local.contributor.firstnameJohn Ben
local.contributor.firstnameNatalie Ken
local.contributor.firstnameDavid Jen
local.contributor.firstnameImtiaz A Sen
local.contributor.firstnameAlison Len
local.subject.for2008070201 Animal Breedingen
local.subject.seo2008830301 Beef Cattleen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolAnimal Genetics and Breeding Uniten
local.profile.emailnconnor2@une.edu.auen
local.profile.emaildjohnsto@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeSwitzerlanden
local.identifier.runningnumber593154en
local.format.startpage1en
local.format.endpage23en
local.identifier.scopusid85101674298en
local.peerreviewedYesen
local.identifier.volume12en
local.access.fulltextYesen
local.contributor.lastnameMuelleren
local.contributor.lastnameColeen
local.contributor.lastnameConnorsen
local.contributor.lastnameJohnstonen
local.contributor.lastnameRandhawaen
local.contributor.lastnameVan Eenennaamen
dc.identifier.staffune-id:nconnor2en
dc.identifier.staffune-id:djohnstoen
local.profile.orcid0000-0003-4866-4757en
local.profile.orcid0000-0002-4995-8311en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/30541en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleComparison of Gene Editing Versus Conventional Breeding to Introgress the POLLED Allele Into the Tropically Adapted Australian Beef Cattle Populationen
local.relation.fundingsourcenoteThis project was supported in part by funds from the USDA National Institute of Food and Agriculture National Research Initiative Competitive Grant no. 2015-67015-23316 (T. S. Sonstegard, PD), and a Henry A. Jastro graduate research award to MM. MM was supported by the National Institute for Food and Agriculture National Needs Graduate and Postgraduate Fellowship no. 2017-38420-26790 from the United States Department of Agriculture. JC was supported by appropriated project 8042-31000-002-00-D, “Improving Dairy Animals by Increasing Accuracy of Genomic Prediction, Evaluating New Traits, and Redefining Selection Goals,” of the Agricultural Research Service of the United States Department of Agriculture.en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorMueller, Maci Len
local.search.authorCole, John Ben
local.search.authorConnors, Natalie Ken
local.search.authorJohnston, David Jen
local.search.authorRandhawa, Imtiaz A Sen
local.search.authorVan Eenennaam, Alison Len
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/3028e6f0-cb0b-41b5-9e13-ab718a9e57a2en
local.uneassociationYesen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.identifier.wosid000621394300001en
local.year.published2021en
local.fileurl.openhttps://rune.une.edu.au/web/retrieve/3028e6f0-cb0b-41b5-9e13-ab718a9e57a2en
local.fileurl.openpublishedhttps://rune.une.edu.au/web/retrieve/3028e6f0-cb0b-41b5-9e13-ab718a9e57a2en
local.subject.for2020300305 Animal reproduction and breedingen
local.subject.seo2020100401 Beef cattleen
Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
Journal Article
School of Science and Technology
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