Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/30400
Title: Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression
Contributor(s): Culverhouse, R C (author); Saccone, N L (author); Horton, A C (author); Ma, Y (author); Anstey, K J (author); Banaschewski, T (author); Burmeister, M (author); Cohen-Woods, S (author); Etain, B (author); Fisher, H L (author); Goldman, N (author); Guillaume, S (author); Horwood, J (author); Juhasz, G (author); Lester, K J (author); Mandelli, L (author); Middeldorp, C M (author); Olié, E (author); Villafuerte, S (author); Air, T M (author); Araya, R (author); Bowes, L (author); Burns, R (author); Byrne, E M (author); Coffey, C (author); Coventry, W L  (author)orcid ; Gawronski, K A B (author); Glei, D (author); Hatzimanolis, A (author); Hottenga, J-J (author); Jaussent, I (author); Jawahar, C (author); Jennen-Steinmetz, C (author); Kramer, J R (author); Lajnef, M (author); Little, K (author); Zu Schwabedissen, H M (author); Nauck, M (author); Nederhof, E (author); Petschner, P (author); Peyrot, W J (author); Schwahn, C (author); Sinnamon, G (author); Stacey, D (author); Tian, Y (author); Toben, C (author); Van Der Auwera, S (author); Wainwright, N (author); Wang, J-C (author); Willemsen, G (author); Anderson, I M (author); Arolt, V (author); Åslund, C (author); Bagdy, G (author); Baune, B T (author); Bellivier, F (author); Boomsma, D I (author); Courtet, P (author); Dannlowski, U (author); De Geus, E J C (author); Deakin, J F W (author); Easteal, S (author); Eley, T (author); Fergusson, D M (author); Goate, A M (author); Gonda, X (author); Grabe, H J (author); Holzman, C (author); Johnson, E O (author); Kennedy, M (author); Laucht, M (author); Martin, N G (author); Munafò, M R (author); Nilsson, K W (author); Oldehinkel, A J (author); Olsson, C A (author); Ormel, J (author); Otte, C (author); Patton, G C (author); Penninx, B W J H (author); Ritchie, K (author); Sarchiapone, M (author); Scheid, J M (author); Serretti, A (author); Smit, J H (author); Stefanis, N C (author); Surtees, P G (author); Völzke, H (author); Weinstein, M (author); Whooley, M (author); Nurnberger, J I (author); Breslau, N (author); Bierut, L J (author)
Publication Date: 2018
Early Online Version: 2017-04-04
DOI: 10.1038/mp.2017.44
Handle Link: https://hdl.handle.net/1959.11/30400
Abstract: The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated much interest, research and controversy since first proposed in 2003. Multiple meta-analyses combining results from heterogeneous analyses have not settled the issue. To determine the magnitude of the interaction and the conditions under which it might be observed, we performed new analyses on 31 data sets containing 38 802 European ancestry subjects genotyped for 5-HTTLPR and assessed for depression and childhood maltreatment or other stressful life events, and meta-analysed the results. Analyses targeted two stressors (narrow, broad) and two depression outcomes (current, lifetime). All groups that published on this topic prior to the initiation of our study and met the assessment and sample size criteria were invited to participate. Additional groups, identified by consortium members or self-identified in response to our protocol (published prior to the start of analysis) with qualifying unpublished data, were also invited to participate. A uniform data analysis script implementing the protocol was executed by each of the consortium members. Our findings do not support the interaction hypothesis. We found no subgroups or variable definitions for which an interaction between stress and 5-HTTLPR genotype was statistically significant. In contrast, our findings for the main effects of life stressors (strong risk factor) and 5-HTTLPR genotype (no impact on risk) are strikingly consistent across our contributing studies, the original study reporting the interaction and subsequent meta-analyses. Our conclusion is that if an interaction exists in which the S allele of 5-HTTLPR increases risk of depression only in stressed individuals, then it is not broadly generalisable, but must be of modest effect size and only observable in limited situations.
Publication Type: Journal Article
Source of Publication: Molecular Psychiatry, v.23, p. 133-142
Publisher: Nature Publishing Group
Place of Publication: United Kingdom
ISSN: 1476-5578
1359-4184
Fields of Research (FoR) 2008: 111714 Mental Health
060405 Gene Expression (incl. Microarray and other genome-wide approaches)
Fields of Research (FoR) 2020: 310505 Gene expression (incl. microarray and other genome-wide approaches)
Socio-Economic Objective (SEO) 2008: 920410 Mental Health
920110 Inherited Diseases (incl. Gene Therapy)
Socio-Economic Objective (SEO) 2020: 200409 Mental health
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Psychology

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