Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/23322
Title: 1D Self-Assembly and Ice Recrystallization Inhibition Activity of Antifreeze Glycopeptide-Functionalized Perylene Bisimides
Contributor(s): Adam, Madeleine K (author); Jarrett-Wilkins, Charles (author); Ben, Robert N (author); Wilkinson, Brendan (author)orcid ; Beards, Michael (author); Staykov, Emiliyan (author); MacFarlane, Liam R (author); Bell, Toby D M (author); Matthews, Jacqueline M (author); Manners, Ian (author); Faul, Charl F J (author); Moens, Pierre (author)orcid 
Publication Date: 2018
DOI: 10.1002/chem.201800857
Handle Link: https://hdl.handle.net/1959.11/23322
Abstract: Antifreeze glycoproteins (AFGPs) are polymeric natural products that have drawn considerable interest in diverse research fields owing to their potent ice recrystallization inhibition (IRI) activity. Self-assembled materials have emerged as a promising class of biomimetic ice growth inhibitor, yet the development of AFGP-based supramolecular materials that emulate the aggregative behavior of AFGPs have not yet been reported. Here, we demonstrate the first example of the 1D self-assembly and IRI activity of AFGP-functionalized perylene bisimides (AFGP-PBIs). Glycopeptide-functionalized PBIs underwent 1D self-assembly in water and showed modest IRI activity, which could be tuned through substitution of the PBI core. This work presents essential proof-of-principle for the development of novel IRIs as potential supramolecular cryoprotectans and glycoprotein mimics.
Publication Type: Journal Article
Grant Details: ARC/DE130101673
Source of Publication: Chemistry: A European Journal, 24(31), p. 7834-7839
Publisher: Wiley-VCH Verlag GmbH & Co KGaA
Place of Publication: Germany
ISSN: 0947-6539
1521-3765
Field of Research (FOR): 030499 Medicinal and Biomolecular Chemistry not elsewhere classified
030302 Nanochemistry and Supramolecular Chemistry
030301 Chemical Characterisation of Materials
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article

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