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https://hdl.handle.net/1959.11/22986| Title: | Synthesis of N-Propargyl Iminosugar Scaffolds for Compound Library Generation using Click Chemistry | Contributor(s): | Wilkinson, Brendan (author) ; Bornaghi, Laurent F (author); Lopez, Marie (author); Healy, Peter C (author); Poulsen, Sally-Ann (author); Houston, Todd A (author) |
Publication Date: | 2010 | DOI: | 10.1071/ch09426 | Handle Link: | https://hdl.handle.net/1959.11/22986 | Abstract: | We have developed an efficient synthesis of N-propargyl iminosugars for use in diversity-oriented library development. Through a common, crystalline intermediate both piperidine and azepane scaffolds can be prepared with an alkyne functional group, allowing for further elaboration through reaction with azides. | Publication Type: | Journal Article | Source of Publication: | Australian Journal of Chemistry, 63(5), p. 821-829 | Publisher: | CSIRO Publishing | Place of Publication: | Australia | ISSN: | 1445-0038 0004-9425 |
Fields of Research (FoR) 2008: | 030503 Organic Chemical Synthesis 030401 Biologically Active Molecules 030499 Medicinal and Biomolecular Chemistry not elsewhere classified |
Fields of Research (FoR) 2020: | 340401 Biologically active molecules 340503 Organic chemical synthesis 340499 Medicinal and biomolecular chemistry not elsewhere classified |
Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences 970103 Expanding Knowledge in the Chemical Sciences 929999 Health not elsewhere classified |
Socio-Economic Objective (SEO) 2020: | 280102 Expanding knowledge in the biological sciences 200199 Clinical health not elsewhere classified 280105 Expanding knowledge in the chemical sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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| Appears in Collections: | Journal Article School of Science and Technology |
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