Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/22984| Title: | Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors | Contributor(s): | Yeoh, Kar Kheng (author); Butters, Terry D (author); Wilkinson, Brendan (author) ; Fairbanks, Antony J (author) |
Publication Date: | 2009 | DOI: | 10.1016/j.carres.2009.01.001 | Handle Link: | https://hdl.handle.net/1959.11/22984 | Abstract: | A series of potential UDP-sugar mimics were readily synthesised by copper(I) catalysed modified Huisgen cycloaddition of the corresponding a-propargyl glycosides with 5-azido uridine in aqueous solution. None of the compounds accessed displayed significant inhibitory activity at concentrations of up to 4.5 mM in an assay against bovine milk b-1,4-galactosyltransferase. | Publication Type: | Journal Article | Source of Publication: | Carbohydrate Research, 344(5), p. 586-591 | Publisher: | Pergamon Press | Place of Publication: | United Kingdom | ISSN: | 1873-426X 0008-6215 |
Fields of Research (FoR) 2008: | 030401 Biologically Active Molecules 030503 Organic Chemical Synthesis 030499 Medicinal and Biomolecular Chemistry not elsewhere classified |
Fields of Research (FoR) 2020: | 340401 Biologically active molecules 340499 Medicinal and biomolecular chemistry not elsewhere classified 340503 Organic chemical synthesis |
Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences 970103 Expanding Knowledge in the Chemical Sciences |
Socio-Economic Objective (SEO) 2020: | 280102 Expanding knowledge in the biological sciences 280105 Expanding knowledge in the chemical sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
|---|---|
| Appears in Collections: | Journal Article School of Science and Technology |
Files in This Item:
| File | Description | Size | Format |
|---|
SCOPUSTM
Citations
37
checked on Mar 23, 2024
Page view(s)
1,518
checked on Mar 3, 2024
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.