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Title: Synthesis of MUC1-lipopeptide chimeras
Contributor(s): Wilkinson, Brendan  (author)orcid ; Malins, Lara R (author); Chun, Candy K Y (author); Payne, Richard J (author)
Publication Date: 2010
DOI: 10.1039/c0cc01360a
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Abstract: An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the TN and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam3CysSer were synthesised in high yields using a fragment-based condensation strategy.
Publication Type: Journal Article
Source of Publication: Chemical Communications, 46(34), p. 6249-6251
Publisher: Royal Society of Chemistry
Place of Publication: United Kingdom
ISSN: 1364-548X
Field of Research (FOR): 030503 Organic Chemical Synthesis
030406 Proteins and Peptides
030401 Biologically Active Molecules
Socio-Economic Outcome Codes: 970103 Expanding Knowledge in the Chemical Sciences
970106 Expanding Knowledge in the Biological Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Science and Technology

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