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https://hdl.handle.net/1959.11/22918| Title: | Stereoselective synthesis of β-arabino glycosyl sulfones as potential inhibitors of mycobacterial cell wall biosynthesis | Contributor(s): | Ayers, Benjamin (author); Long, Hilary (author); Sim, Edith (author); Smellie, Iain A (author); Wilkinson, Brendan (author) ; Fairbanks, Antony J (author) |
Publication Date: | 2009 | DOI: | 10.1016/j.carres.2009.02.006 | Handle Link: | https://hdl.handle.net/1959.11/22918 | Abstract: | A series of β-arabino glycosyl sulfones with varying alkyl chain lengths were synthesised in a stereoselective fashion as putative mimics of decaprenolphosphoarabinose (DPA), and as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity with marked dependence on alkyl chain length, which was maximal for a C-12 chain. | Publication Type: | Journal Article | Source of Publication: | Carbohydrate Research, 344(6), p. 739-746 | Publisher: | Pergamon Press | Place of Publication: | United Kingdom | ISSN: | 1873-426X 0008-6215 |
Fields of Research (FoR) 2008: | 030401 Biologically Active Molecules 030499 Medicinal and Biomolecular Chemistry not elsewhere classified 030503 Organic Chemical Synthesis |
Fields of Research (FoR) 2020: | 340499 Medicinal and biomolecular chemistry not elsewhere classified 340503 Organic chemical synthesis 340401 Biologically active molecules |
Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences 970103 Expanding Knowledge in the Chemical Sciences 929999 Health not elsewhere classified |
Socio-Economic Objective (SEO) 2020: | 200199 Clinical health not elsewhere classified 280105 Expanding knowledge in the chemical sciences 280102 Expanding knowledge in the biological sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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| Appears in Collections: | Journal Article School of Science and Technology |
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