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Title: Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis
Contributor(s): Wilkinson, Brendan  (author)orcid ; Long, Hilary (author); Sim, Edith (author); Fairbanks, Antony J (author)
Publication Date: 2008
DOI: 10.1016/j.bmcl.2008.09.082
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Abstract: A series of arabino glycosyl triazoles with varying hydrophobic groups were synthesised as putative mimics of decaprenolphosphoarabinose (DPA) as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity, with strong dependence on the identity of the hydrophobic side chain.
Publication Type: Journal Article
Source of Publication: Bioorganic & Medicinal Chemistry Letters, 18(23), p. 6265-6267
Publisher: Pergamon Press
Place of Publication: United Kingdom
ISSN: 0960-894X
Field of Research (FOR): 030499 Medicinal and Biomolecular Chemistry not elsewhere classified
030401 Biologically Active Molecules
030503 Organic Chemical Synthesis
Socio-Economic Outcome Codes: 970106 Expanding Knowledge in the Biological Sciences
929999 Health not elsewhere classified
970103 Expanding Knowledge in the Chemical Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Science and Technology

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