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https://hdl.handle.net/1959.11/22917| Title: | Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis | Contributor(s): | Wilkinson, Brendan (author) ; Long, Hilary (author); Sim, Edith (author); Fairbanks, Antony J (author) |
Publication Date: | 2008 | DOI: | 10.1016/j.bmcl.2008.09.082 | Handle Link: | https://hdl.handle.net/1959.11/22917 | Abstract: | A series of arabino glycosyl triazoles with varying hydrophobic groups were synthesised as putative mimics of decaprenolphosphoarabinose (DPA) as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity, with strong dependence on the identity of the hydrophobic side chain. | Publication Type: | Journal Article | Source of Publication: | Bioorganic & Medicinal Chemistry Letters, 18(23), p. 6265-6267 | Publisher: | Pergamon Press | Place of Publication: | United Kingdom | ISSN: | 1464-3405 0960-894X |
Fields of Research (FoR) 2008: | 030499 Medicinal and Biomolecular Chemistry not elsewhere classified 030401 Biologically Active Molecules 030503 Organic Chemical Synthesis |
Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences 929999 Health not elsewhere classified 970103 Expanding Knowledge in the Chemical Sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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| Appears in Collections: | Journal Article School of Science and Technology |
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