Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/22789
Title: Photoswitchable Janus glycodendrimer micelles as multivalent inhibitors of LecA and LecB from Pseudomonas aeruginosa
Contributor(s): Hu, Yingxue (author); Beshr, Ghamdan (author); Garvey, Christopher J (author); Tabor, Rico F (author); Titz, Alexander (author); Wilkinson, Brendan (author)orcid 
Publication Date: 2017
DOI: 10.1016/j.colsurfb.2017.08.016
Handle Link: https://hdl.handle.net/1959.11/22789
Abstract: The first example of the self-assembly and lectin binding properties of photoswitchable glycodendrimer micelles is reported. Light-addressable micelles were assembled from a library of 12 amphiphilic Janus glycodendrimers composed of variable carbohydrate head groups and hydrophobic tail groups linked to an azobenzene core. Spontaneous association in water gave cylindrical micelles with uniform size distribution as determined by dynamic light scattering (DLS) and small angle neutron scattering (SANS). Trans-cis photoisomerization of the azobenzene dendrimer core was used to probe the self-assembly behaviour and lectin binding properties of cylindrical micelles, revealing moderate-to-potent inhibition of lectins LecA and LecB from Pseudomonas aeruginosa.
Publication Type: Journal Article
Grant Details: ARC/DE130101673
Source of Publication: Colloids and Surfaces B: Biointerfaces, v.159, p. 605-612
Publisher: Elsevier BV
Place of Publication: The Netherlands
ISSN: 0927-7765
1873-4367
Field of Research (FOR): 060501 Bacteriology
030503 Organic Chemical Synthesis
030304 Physical Chemistry of Materials
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Statistics to Oct 2018: Visitors: 9
Views: 41
Downloads: 0
Appears in Collections:Journal Article

Files in This Item:
2 files
File Description SizeFormat 
Show full item record

SCOPUSTM   
Citations

2
checked on Nov 30, 2018

Page view(s)

56
checked on Feb 7, 2019
Google Media

Google ScholarTM

Check

Altmetric

SCOPUSTM   
Citations

 

WEB OF SCIENCETM
Citations

 

Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.