Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/22789
Title: | Photoswitchable Janus glycodendrimer micelles as multivalent inhibitors of LecA and LecB from Pseudomonas aeruginosa | Contributor(s): | Hu, Yingxue (author); Beshr, Ghamdan (author); Garvey, Christopher J (author); Tabor, Rico F (author); Titz, Alexander (author); Wilkinson, Brendan (author)![]() |
Publication Date: | 2017 | DOI: | 10.1016/j.colsurfb.2017.08.016 | Handle Link: | https://hdl.handle.net/1959.11/22789 | Abstract: | The first example of the self-assembly and lectin binding properties of photoswitchable glycodendrimer micelles is reported. Light-addressable micelles were assembled from a library of 12 amphiphilic Janus glycodendrimers composed of variable carbohydrate head groups and hydrophobic tail groups linked to an azobenzene core. Spontaneous association in water gave cylindrical micelles with uniform size distribution as determined by dynamic light scattering (DLS) and small angle neutron scattering (SANS). Trans-cis photoisomerization of the azobenzene dendrimer core was used to probe the self-assembly behaviour and lectin binding properties of cylindrical micelles, revealing moderate-to-potent inhibition of lectins LecA and LecB from Pseudomonas aeruginosa. | Publication Type: | Journal Article | Grant Details: | ARC/DE130101673 | Source of Publication: | Colloids and Surfaces B: Biointerfaces, v.159, p. 605-612 | Publisher: | Elsevier BV | Place of Publication: | Netherlands | ISSN: | 1873-4367 0927-7765 |
Fields of Research (FoR) 2008: | 060501 Bacteriology 030503 Organic Chemical Synthesis 030304 Physical Chemistry of Materials |
Fields of Research (FoR) 2020: | 310701 Bacteriology 340305 Physical properties of materials 340503 Organic chemical synthesis |
Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences 970102 Expanding Knowledge in the Physical Sciences 970103 Expanding Knowledge in the Chemical Sciences |
Socio-Economic Objective (SEO) 2020: | 280120 Expanding knowledge in the physical sciences 280102 Expanding knowledge in the biological sciences 280105 Expanding knowledge in the chemical sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Science and Technology |
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