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Title: Sweetness and light: design and applications of photo-responsive glycoconjugates
Contributor(s): Hu, Yingxue (author); Tabor, Rico F (author); Wilkinson, Brendan  (author)orcid 
Publication Date: 2015
DOI: 10.1039/c4ob02296c
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Abstract: Carbohydrate-protein binding is a supramolecular recognition process that underpins myriad biological events. However, the precise conformational and configurational requirements for biomolecular recognition are often poorly understood, since such phenomena often occur in a strongly spatiotemporal manner. Photoswitchable glycoconjugates have emerged as promising investigational tools for probing carbohydrate-protein recognition and for controlling bacterial adhesion. Reversible photoisomerisation, in particular that of azobenzene glycoconjugates, has also been exploited as a promising strategy for controlling supramolecular self-assembly and macroscopic properties, thereby facilitating the development of light responsive carbohydrate-based materials. The following review will highlight the recent advances in the design and applications of photoswitchable glycoconjugates, paying particular attention to the application of light as a stimulus for modulating protein and cellular adhesion, amphiphilicity and supramolecular assembly of carbohydrate-based materials.
Publication Type: Journal Article
Grant Details: ARC/DE130101673
Source of Publication: Organic & Biomolecular Chemistry, 13(8), p. 2216-2225
Publisher: Royal Society of Chemistry
Place of Publication: United Kingdom
ISSN: 1477-0539
Field of Research (FOR): 030401 Biologically Active Molecules
030303 Optical Properties of Materials
030503 Organic Chemical Synthesis
Socio-Economic Outcome Codes: 970103 Expanding Knowledge in the Chemical Sciences
970106 Expanding Knowledge in the Biological Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Science and Technology

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