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Title: Self-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam3CysSer
Contributor(s): Wilkinson, Brendan  (author)orcid ; Day, Stephanie (author); Malins, Lara R (author); Apostolopoulos, Vasso (author); Payne, Richard J (author)
Publication Date: 2011
DOI: 10.1002/anie.201006115
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Abstract: The aberrant glycosylation of cell surface mucin glycoproteins such as MUC1 and the overexpression of highly truncated, tumor-associated carbohydrate antigens (TACAs) are strongly correlated with tumor metastasis and poor prognosis.[¹] Such TACAs, including the well-studied TN and T antigens and their sialylated derivatives, are important targets for the development of antigen-specific carbohydrate vaccines.[²] However, these structures are self antigens that generally elicit T-cell independent immune responses which are tolerated by the immune system and lead to poor immunogenicity.
Publication Type: Journal Article
Source of Publication: Angewandte Chemie (International Edition), 50(7), p. 1635-1639
Publisher: Wiley-VCH Verlag GmbH & Co KGaA
Place of Publication: Germany
ISSN: 1521-3773
Field of Research (FOR): 030406 Proteins and Peptides
030401 Biologically Active Molecules
030503 Organic Chemical Synthesis
Socio-Economic Outcome Codes: 970106 Expanding Knowledge in the Biological Sciences
970103 Expanding Knowledge in the Chemical Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article

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