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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20673
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dc.contributor.authorWilkinson, Brendanen
dc.contributor.authorDay, Stephanieen
dc.contributor.authorMalins, Lara Ren
dc.contributor.authorApostolopoulos, Vassoen
dc.contributor.authorPayne, Richard Jen
dc.date.accessioned2017-05-05T14:52:00Z-
dc.date.issued2011-
dc.identifier.citationAngewandte Chemie (International Edition), 50(7), p. 1635-1639en
dc.identifier.issn1521-3773en
dc.identifier.issn1433-7851en
dc.identifier.urihttps://hdl.handle.net/1959.11/20673-
dc.description.abstractThe aberrant glycosylation of cell surface mucin glycoproteins such as MUC1 and the overexpression of highly truncated, tumor-associated carbohydrate antigens (TACAs) are strongly correlated with tumor metastasis and poor prognosis.[¹] Such TACAs, including the well-studied TN and T antigens and their sialylated derivatives, are important targets for the development of antigen-specific carbohydrate vaccines.[²] However, these structures are self antigens that generally elicit T-cell independent immune responses which are tolerated by the immune system and lead to poor immunogenicity.en
dc.languageenen
dc.publisherWiley-VCH Verlag GmbH & Co KGaAen
dc.relation.ispartofAngewandte Chemie (International Edition)en
dc.titleSelf-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam3CysSeren
dc.typeJournal Articleen
dc.identifier.doi10.1002/anie.201006115en
dc.subject.keywordsBiologically Active Moleculesen
dc.subject.keywordsOrganic Chemical Synthesisen
dc.subject.keywordsProteins and Peptidesen
local.contributor.firstnameBrendanen
local.contributor.firstnameStephanieen
local.contributor.firstnameLara Ren
local.contributor.firstnameVassoen
local.contributor.firstnameRichard Jen
local.subject.for2008030406 Proteins and Peptidesen
local.subject.for2008030401 Biologically Active Moleculesen
local.subject.for2008030503 Organic Chemical Synthesisen
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.subject.seo2008970103 Expanding Knowledge in the Chemical Sciencesen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailbwilkin7@une.edu.auen
local.profile.emailrichard.payne@sydney.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20170323-12083en
local.publisher.placeGermanyen
local.format.startpage1635en
local.format.endpage1639en
local.identifier.scopusid79851470018en
local.peerreviewedYesen
local.identifier.volume50en
local.identifier.issue7en
local.contributor.lastnameWilkinsonen
local.contributor.lastnameDayen
local.contributor.lastnameMalinsen
local.contributor.lastnameApostolopoulosen
local.contributor.lastnamePayneen
dc.identifier.staffune-id:bwilkin7en
local.profile.orcid0000-0003-1866-6540en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:20866en
dc.identifier.academiclevelAcademicen
local.title.maintitleSelf-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam3CysSeren
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorWilkinson, Brendanen
local.search.authorDay, Stephanieen
local.search.authorMalins, Lara Ren
local.search.authorApostolopoulos, Vassoen
local.search.authorPayne, Richard Jen
local.uneassociationUnknownen
local.year.published2011en
local.subject.for2020340407 Proteins and peptidesen
local.subject.for2020340503 Organic chemical synthesisen
local.subject.for2020340401 Biologically active moleculesen
local.subject.seo2020280102 Expanding knowledge in the biological sciencesen
local.subject.seo2020280105 Expanding knowledge in the chemical sciencesen
local.codeupdate.date2022-02-13T16:51:38.384en
local.codeupdate.epersonbwilkin7@une.edu.auen
local.codeupdate.finalisedtrueen
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