Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20596
Title: Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy
Contributor(s): Al Sheikha, Dima (author); Wilkinson, Brendan (author)orcid ; Santhakumar, Gajan (author); Thaysen-Andersen, Morten (author); Payne, Richard J (author)
Publication Date: 2013
DOI: 10.1039/c3ob41363b
Handle Link: https://hdl.handle.net/1959.11/20596
Abstract: The efficient synthesis of homogeneous MUC1 peptide oligomers using sequential ligation reactions in the N-to-C and C-to-N directions is reported. The bi-directional ligation strategy makes use of thioester formation via N → S acyl shift chemistry in combination with peptide ligation reactions and was used to prepare a library of peptide oligomers ranging in molecular mass from 3.8-9.4 kDa, comprised of between 2 and 5 repeats of the MUC1 variable number tandem repeat sequence.
Publication Type: Journal Article
Source of Publication: Organic & Biomolecular Chemistry, 11(36), p. 6090-6096
Publisher: Royal Society of Chemistry
Place of Publication: United Kingdom
ISSN: 1477-0539
1477-0520
Field of Research (FOR): 030503 Organic Chemical Synthesis
030401 Biologically Active Molecules
030406 Proteins and Peptides
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article

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