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https://hdl.handle.net/1959.11/13557
Title: | In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites | Contributor(s): | Andriani, Yosephine (author); Morrow, Isabel C (author); Taran, Elana (author); Edwards, Grant A (author); Schiller, Tara (author); Osman, Azlin F (author); Martin, Darren J (author) | Publication Date: | 2013 | DOI: | 10.1016/j.actbio.2013.05.021 | Handle Link: | https://hdl.handle.net/1959.11/13557 | Abstract: | We have prepared a number of silicone-based thermoplastic polyurethane (TPU) nanocomposites and demonstrated an enhancement of in vitro biostability against metal-ion-induced oxidation for potential use in long-term implantable medical devices. Organoclays based on both low-aspect-ratio hectorites and high-aspect-ratio fluoromicas were evaluated after being dual-modified with two quaternary alkyl ammonium salts with differing degrees of polarity. The resultant nanocomposites were tested for in vitro biostability using physiologically relevant oxidizing conditions. Subsequently, the effects of oxidative treatment on the surface degradation and bulk mechanical integrity of the nanocomposites were investigated and compared with the parent TPUs to identify nanocomposites with the most desirable features for long-term implantation. Here, we demonstrate that the low-aspect-ratio organohectorite was delaminated and well dispersed in the nanocomposites. Importantly, these factors gave rise to the enhanced oxidative stability. In addition, the mechanical properties of all nanocomposites were less adversely affected by the oxidative treatment compared to their parent TPUs. These results suggest the potential for improved mechanical integrity and biostability when suitable dual modified organoclays are incorporated in a silicone-based TPU. | Publication Type: | Journal Article | Source of Publication: | Acta Biomaterialia, 9(9), p. 8308-8317 | Publisher: | Elsevier BV | Place of Publication: | Netherlands | ISSN: | 1878-7568 1742-7061 |
Fields of Research (FoR) 2008: | 030399 Macromolecular and Materials Chemistry not elsewhere classified 030302 Nanochemistry and Supramolecular Chemistry 030306 Synthesis of Materials |
Fields of Research (FoR) 2020: | 340399 Macromolecular and materials chemistry not elsewhere classified 340207 Metal organic frameworks |
Socio-Economic Objective (SEO) 2008: | 970109 Expanding Knowledge in Engineering 970103 Expanding Knowledge in the Chemical Sciences 970106 Expanding Knowledge in the Biological Sciences |
Socio-Economic Objective (SEO) 2020: | 280110 Expanding knowledge in engineering 280105 Expanding knowledge in the chemical sciences 280102 Expanding knowledge in the biological sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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