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Title: Towards a comprehensive recombination map of hotspots in sheep
Contributor(s): Massault, Cecile (author); Henshall, John M (author); Gondro, Cedric (author)orcid ; Van Der Werf, Julius H (author)orcid 
Publication Date: 2011
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Abstract: Recombination rate is positively associated with genetic diversity (Spencer et al. 2006). Hotspots are regions with a higher recombination rate than average, which could be indicative of diversity in the genome. We used genotype data from Illumina OvineSNP50 Bead Chip on 3908 sheep, to first infer sire haplotypes and then detect the recombination events for the whole genome. We found on average over the genome 0.033 recombination events per mega base pair (Mb). Variance of recombination events between individuals was large, but much smaller between sire groups. Breed was found to have a highly significant effect on recombination events over the genome. Heritability of recombination events was found to be medium (0.25 ± 0.09). A recombination map is a useful tool to better understand the mechanisms of diversity, and this information can be used to have more insight in linkage disequilibrium.
Publication Type: Conference Publication
Conference Name: 19th Conference of the Association for the Advancement of Animal Breeding and Genetics, Perth, Australia, 19th - 21st July, 2011
Source of Publication: Breeding Objectives: A New Paradigm, p. 375-378
Publisher: AAABG: Association for the Advancement of Animal Breeding and Genetics
Place of Publication: Perth, Australia
Field of Research (FOR): 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics)
070201 Animal Breeding
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
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Series Name: Proceedings of the AAABG ... Conference
Series Number : 19
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Appears in Collections:Conference Publication
School of Environmental and Rural Science

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