Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/9739
Title: Stress-linked cortisol concentrations in hair: what we know and what we need to know
Contributor(s): Sharpley, Chris  (author)orcid ; McFarlane, James R (author)orcid ; Slominski, Andrzej (author)
Publication Date: 2012
Open Access: Yes
DOI: 10.1515/rns.2011.058Open Access Link
Handle Link: https://hdl.handle.net/1959.11/9739
Open Access Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381079Open Access Link
Abstract: Cortisol has major impacts upon a range of physiological homeostatic mechanisms and plays an important role in stress, anxiety and depression. Although traditionally described as being solely synthesised via the hypothalamic-pituitary-adrenal (HPA) axis, recent animal and human studies indicate that cortisol may also be synthesised via a functionally-equivalent 'peripheral' HPA-like process within the skin, principally within hair follicles, melanocytes, epidermal melanocytes and dermal fibroblasts. Current data indicate that basal levels of cortisol within hair vary across body regions, show diurnal variation effects, respond to the onset and cessation of environmental stressors, and may demonstrate some degree of localisation in those responses. There are conflicting data regarding the presence of variability in cortisol concentrations across the length of the hair shaft, thus challenging the suggestion that hair cortisol may be used as a historical biomarker of stress and questioning the primary origin of cortisol in hair. The need to comprehensively 'map' the hair cortisol response for age, gender, diurnal rhythm and responsivity to stressor type is discussed, plus the major issue of if, and how, the peripheral and central HPA systems communicate.
Publication Type: Journal Article
Source of Publication: Reviews in the Neurosciences, 23(1), p. 111-121
Publisher: Walter de Gruyter GmbH & Co KG
Place of Publication: Berlin, Germany
ISSN: 0334-1763
2191-0200
Field of Research (FOR): 110319 Psychiatry (incl Psychotherapy)
Socio-Economic Outcome Codes: 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Statistics to Oct 2018: Visitors: 91
Views: 92
Downloads: 1
Appears in Collections:Journal Article
School of Science and Technology

Files in This Item:
2 files
File Description SizeFormat 
Show full item record

SCOPUSTM   
Citations

36
checked on Nov 30, 2018

Page view(s)

104
checked on Feb 8, 2019
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.