Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/9739
Title: | Stress-linked cortisol concentrations in hair: what we know and what we need to know | Contributor(s): | Sharpley, Chris (author) ; McFarlane, James R (author) ; Slominski, Andrzej (author) | Publication Date: | 2012 | Open Access: | Yes | DOI: | 10.1515/rns.2011.058 | Handle Link: | https://hdl.handle.net/1959.11/9739 | Open Access Link: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381079 | Abstract: | Cortisol has major impacts upon a range of physiological homeostatic mechanisms and plays an important role in stress, anxiety and depression. Although traditionally described as being solely synthesised via the hypothalamic-pituitary-adrenal (HPA) axis, recent animal and human studies indicate that cortisol may also be synthesised via a functionally-equivalent 'peripheral' HPA-like process within the skin, principally within hair follicles, melanocytes, epidermal melanocytes and dermal fibroblasts. Current data indicate that basal levels of cortisol within hair vary across body regions, show diurnal variation effects, respond to the onset and cessation of environmental stressors, and may demonstrate some degree of localisation in those responses. There are conflicting data regarding the presence of variability in cortisol concentrations across the length of the hair shaft, thus challenging the suggestion that hair cortisol may be used as a historical biomarker of stress and questioning the primary origin of cortisol in hair. The need to comprehensively 'map' the hair cortisol response for age, gender, diurnal rhythm and responsivity to stressor type is discussed, plus the major issue of if, and how, the peripheral and central HPA systems communicate. | Publication Type: | Journal Article | Source of Publication: | Reviews in the Neurosciences, 23(1), p. 111-121 | Publisher: | Walter de Gruyter GmbH | Place of Publication: | Germany | ISSN: | 2191-0200 0334-1763 |
Fields of Research (FoR) 2008: | 110319 Psychiatry (incl Psychotherapy) | Fields of Research (FoR) 2020: | 320221 Psychiatry (incl. psychotherapy) | Socio-Economic Objective (SEO) 2008: | 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified | Socio-Economic Objective (SEO) 2020: | 200199 Clinical health not elsewhere classified | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
---|---|
Appears in Collections: | Journal Article School of Science and Technology |
Files in This Item:
File | Description | Size | Format |
---|
SCOPUSTM
Citations
76
checked on Oct 5, 2024
Page view(s)
1,316
checked on Jun 23, 2024
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.