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Title: The Role of Genes (and Environmental Stress) in Depression: An Update
Contributor(s): Sharpley, Chris  (author)orcid 
Publication Date: 2011
DOI: 10.2174/157340011796391175
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Abstract: Objective: To review recent data on six previously-identified genetic associations with depression, focusing upon issues of samples and instruments, in order to clarify the roles of these genetic variables in depression. Methods: Search the literature from the last four years, tabulate studies and examine the presence of any recent trends. Results: At least one previously-identified genetic association with depression is subject to the confounding effects of age-related dementia, and some others do not have recent supportive data that connect them to depression. In addition, over 300 other genetic factors have recently been identified to have associations with depression. Recent findings regarding one particular polymorphism (the ss 5-HTTLPR) suggest that the "causal" connection between some genes and depression may be via sensitivity to environmental stressors rather than as a result of the genetic predisposition per se. Conclusion: Recent genetic association studies of depression appear to suggest that some of the six previously-identified polymorphisms are not consistently related to depression, and that at least one major "causal" genetic variable may act via increased environmental sensitivity.
Publication Type: Journal Article
Source of Publication: Current Psychiatry Reviews, 7(2), p. 84-95
Publisher: Bentham Science Publishers Ltd
Place of Publication: The Netherlands
ISSN: 1573-4005
Field of Research (FOR): 110319 Psychiatry (incl Psychotherapy)
Socio-Economic Outcome Codes: 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Science and Technology

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