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https://hdl.handle.net/1959.11/9560| Title: | Novel paramagnetic AT₁ receptor antagonists | Contributor(s): | Tan, Nichole PH (author); Taylor, Michelle K (author); Bottle, Steven E (author); Wright, Christine E (author); Ziogas, James (author); White, Jonathan M (author); Schiesser, Carl H (author); Jani, Natya V (author) | Publication Date: | 2011 | DOI: | 10.1039/c1cc14920b | Handle Link: | https://hdl.handle.net/1959.11/9560 | Abstract: | Novel paramagnetic selective angiotensin AT₁ receptor antagonists (sartans) bearing nitroxides (3, 4) have been prepared and their pharmacology evaluated in vitro as well as in vivo. Compounds 3, 4 proved to be effective sartans with pKB estimates in the range 6.2-9.1. In addition, the sodium salt (11) of 4 (R = Bu) is able to protect against vascular injury in hypertensive rats as determined by its ability to attenuate the development of intimal thickening caused by balloon injury of the carotid artery. | Publication Type: | Journal Article | Source of Publication: | Chemical Communications, 47(44), p. 12083-12085 | Publisher: | Royal Society of Chemistry | Place of Publication: | United Kingdom | ISSN: | 1364-548X 1359-7345 |
Fields of Research (FoR) 2008: | 030503 Organic Chemical Synthesis 030401 Biologically Active Molecules |
Socio-Economic Objective (SEO) 2008: | 920103 Cardiovascular System and Diseases 970103 Expanding Knowledge in the Chemical Sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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| Appears in Collections: | Journal Article |
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