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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/9560
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dc.contributor.authorTan, Nichole PHen
dc.contributor.authorTaylor, Michelle Ken
dc.contributor.authorBottle, Steven Een
dc.contributor.authorWright, Christine Een
dc.contributor.authorZiogas, Jamesen
dc.contributor.authorWhite, Jonathan Men
dc.contributor.authorSchiesser, Carl Hen
dc.contributor.authorJani, Natya Ven
dc.date.accessioned2012-02-27T15:05:00Z-
dc.date.issued2011-
dc.identifier.citationChemical Communications, 47(44), p. 12083-12085en
dc.identifier.issn1364-548Xen
dc.identifier.issn1359-7345en
dc.identifier.urihttps://hdl.handle.net/1959.11/9560-
dc.description.abstractNovel paramagnetic selective angiotensin AT₁ receptor antagonists (sartans) bearing nitroxides (3, 4) have been prepared and their pharmacology evaluated in vitro as well as in vivo. Compounds 3, 4 proved to be effective sartans with pKB estimates in the range 6.2-9.1. In addition, the sodium salt (11) of 4 (R = Bu) is able to protect against vascular injury in hypertensive rats as determined by its ability to attenuate the development of intimal thickening caused by balloon injury of the carotid artery.en
dc.languageenen
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofChemical Communicationsen
dc.titleNovel paramagnetic AT₁ receptor antagonistsen
dc.typeJournal Articleen
dc.identifier.doi10.1039/c1cc14920ben
dc.subject.keywordsBiologically Active Moleculesen
dc.subject.keywordsOrganic Chemical Synthesisen
local.contributor.firstnameNichole PHen
local.contributor.firstnameMichelle Ken
local.contributor.firstnameSteven Een
local.contributor.firstnameChristine Een
local.contributor.firstnameJamesen
local.contributor.firstnameJonathan Men
local.contributor.firstnameCarl Hen
local.contributor.firstnameNatya Ven
local.subject.for2008030503 Organic Chemical Synthesisen
local.subject.for2008030401 Biologically Active Moleculesen
local.subject.seo2008920103 Cardiovascular System and Diseasesen
local.subject.seo2008970103 Expanding Knowledge in the Chemical Sciencesen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailmtaylo53@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20120120-171014en
local.publisher.placeUnited Kingdomen
local.format.startpage12083en
local.format.endpage12085en
local.identifier.scopusid80155165710en
local.peerreviewedYesen
local.identifier.volume47en
local.identifier.issue44en
local.contributor.lastnameTanen
local.contributor.lastnameTayloren
local.contributor.lastnameBottleen
local.contributor.lastnameWrighten
local.contributor.lastnameZiogasen
local.contributor.lastnameWhiteen
local.contributor.lastnameSchiesseren
local.contributor.lastnameJanien
dc.identifier.staffune-id:mtaylo53en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:9751en
dc.identifier.academiclevelAcademicen
local.title.maintitleNovel paramagnetic AT₁ receptor antagonistsen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorTan, Nichole PHen
local.search.authorTaylor, Michelle Ken
local.search.authorBottle, Steven Een
local.search.authorWright, Christine Een
local.search.authorZiogas, Jamesen
local.search.authorWhite, Jonathan Men
local.search.authorSchiesser, Carl Hen
local.search.authorJani, Natya Ven
local.uneassociationUnknownen
local.year.published2011en
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