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https://hdl.handle.net/1959.11/8065
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wu, ACK | en |
dc.contributor.author | Grondahl, L | en |
dc.contributor.author | Jack, KS | en |
dc.contributor.author | Foo, MX | en |
dc.contributor.author | Trau, M | en |
dc.contributor.author | Hume, DA | en |
dc.contributor.author | Cassady, Alan | en |
dc.date.accessioned | 2011-07-15T16:28:00Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Biomaterials, 27(27), p. 4715-4725 | en |
dc.identifier.issn | 1878-5905 | en |
dc.identifier.issn | 0142-9612 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/8065 | - |
dc.description.abstract | This study evaluates the pro-inflammatory response to the thermoplastic biopolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) through the analysis of cellular responses in vitro. The murine macrophage RAW264.7 cell line was cultured on solvent cast PHBV films, which was found to induce pro-inflammatory activity that required direct contact between the material and the macrophages. The identity of the pro-inflammatory stimulus was determined by culturing bone marrow-derived macrophages from bacterial lipopolysaccharide (LPS) hyporesponsive C3H/HeJ mice and CpG non-responsive TLR9–/– mice on PHBV. The lack of a pro-inflammatory response by the C3H/HeJ cells indicates that the pro-inflammatory agent present within PHBV is predominately LPS while the TLR9–/– macrophages confirmed that CpG-containing bacterial DNA is unlikely to contribute to the activity. A series of purification procedures was evaluated and one procedure was developed that utilized hydrogen peroxide treatment in solution. The optimized purification was found to substantially reduce the pro-inflammatory response to PHBV without adversely affecting either the molecular structure or molecular weight of the material thereby rendering it more amenable for use as a biomaterial in vivo. | en |
dc.language | en | en |
dc.publisher | Elsevier BV | en |
dc.relation.ispartof | Biomaterials | en |
dc.title | Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate) | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1016/j.biomaterials.2006.05.010 | en |
dc.subject.keywords | Medical Devices | en |
local.contributor.firstname | ACK | en |
local.contributor.firstname | L | en |
local.contributor.firstname | KS | en |
local.contributor.firstname | MX | en |
local.contributor.firstname | M | en |
local.contributor.firstname | DA | en |
local.contributor.firstname | Alan | en |
local.subject.for2008 | 090304 Medical Devices | en |
local.subject.seo2008 | 970111 Expanding Knowledge in the Medical and Health Sciences | en |
local.profile.school | School of Science and Technology | en |
local.profile.email | acassady@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20110715-114640 | en |
local.publisher.place | Netherlands | en |
local.format.startpage | 4715 | en |
local.format.endpage | 4725 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 27 | en |
local.identifier.issue | 27 | en |
local.contributor.lastname | Wu | en |
local.contributor.lastname | Grondahl | en |
local.contributor.lastname | Jack | en |
local.contributor.lastname | Foo | en |
local.contributor.lastname | Trau | en |
local.contributor.lastname | Hume | en |
local.contributor.lastname | Cassady | en |
dc.identifier.staff | une-id:acassady | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:8239 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate) | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Wu, ACK | en |
local.search.author | Grondahl, L | en |
local.search.author | Jack, KS | en |
local.search.author | Foo, MX | en |
local.search.author | Trau, M | en |
local.search.author | Hume, DA | en |
local.search.author | Cassady, Alan | en |
local.uneassociation | Unknown | en |
local.year.published | 2006 | en |
Appears in Collections: | Journal Article School of Science and Technology |
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