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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/64456
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dc.contributor.authorWilliams, Rebeccaen
dc.contributor.authorCohen, Alexanderen
dc.contributor.authorLebel, R Marcen
dc.contributor.authorMacDonald, M Ethanen
dc.contributor.authorWang, Yangen
dc.contributor.authorPike, G Bruceen
dc.date.accessioned2025-01-11T09:38:00Z-
dc.date.available2025-01-11T09:38:00Z-
dc.date.issued2024-05-
dc.identifier.citationISMRM & ISMRT 2024 Annual Meeting & Exhibition, 4th - 9th May, 2024, Singaporeen
dc.identifier.urihttps://hdl.handle.net/1959.11/64456-
dc.description.abstract<p><b>Motivation:</b> Resting CMRO<sub>2</sub> is a marker of brain health that may inform typical and pathological brain aging. However, there is conflicting literature describing how CMRO<sub>2</sub> changes across the lifespan, which may be influenced by extraneous variables such as sex and end-tidal partial pressure of carbon dioxide (P<sub>ET</sub>CO<sub>2</sub>).</p> <p><b>Goal(s):</b> This study aimed to evaluate CMRO<sub>2</sub> changes across the lifespan, after considering these possible confounding variables.</p> <p><b>Approach:</b> Dual-calibrated BOLD fMRI quantified grey matter absolute CMRO<sub>2</sub> in 83 participants.</p> <p><b>Results:</b> Sex and age significantly predicted CMRO<sub>2</sub>. Females had higher CMRO<sub>2</sub> than males, and CMRO<sub>2</sub> decreased with increasing age for females.</p> <p><b>Impact:</b> Grey matter CMRO<sub>2</sub> decreases in normal healthy aging. Considering both sexes, the CMRO<sub>2</sub> decline rate was -0.88 per year, after accounting for P<sub>ET</sub>CO<sub>2</sub> and sex. When males and females were analysed separately, females only showed a significant decline with age.</p>en
dc.languageenen
dc.publisherInternational Society for Magnetic Resonance in Medicineen
dc.relation.ispartofISMRM & ISMRT 2024 Annual Meeting & Exhibition, 4th - 9th May, 2024, Singaporeen
dc.titleSex Differences and Age-Related Decline in Absolute Cerebral Metabolic Rate of Oxygen (CMRO2) Consumptionen
dc.typeConference Publicationen
dc.relation.conferenceISMRM/ISMRT 2024: Annual Meeting & Exhibitionen
local.contributor.firstnameRebeccaen
local.contributor.firstnameAlexanderen
local.contributor.firstnameR Marcen
local.contributor.firstnameM Ethanen
local.contributor.firstnameYangen
local.contributor.firstnameG Bruceen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailrwilli90@une.edu.auen
local.output.categoryE3en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.date.conference4th - 9th May, 2024en
local.conference.placeSingaporeen
local.publisher.placeUnited State of Americaen
local.contributor.lastnameWilliamsen
local.contributor.lastnameCohenen
local.contributor.lastnameLebelen
local.contributor.lastnameMacDonalden
local.contributor.lastnameWangen
local.contributor.lastnamePikeen
dc.identifier.staffune-id:rwilli90en
local.profile.orcid0000-0002-8949-1197en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/64456en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleSex Differences and Age-Related Decline in Absolute Cerebral Metabolic Rate of Oxygen (CMRO2) Consumptionen
local.output.categorydescriptionE3 Extract of Scholarly Conference Publicationen
local.relation.urlhttps://archive.ismrm.org/2024/3445.htmlen
local.conference.detailsISMRM/ISMRT 2024: Annual Meeting & Exhibition, Singapore, 4th - 9th May, 2024en
local.search.authorWilliams, Rebeccaen
local.search.authorCohen, Alexanderen
local.search.authorLebel, R Marcen
local.search.authorMacDonald, M Ethanen
local.search.authorWang, Yangen
local.search.authorPike, G Bruceen
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/9c0ea547-5601-4fec-acae-d3afb87eab52en
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/6b38ffb2-feca-4412-bb1a-fe6c8ace6ff5en
local.uneassociationNoen
local.atsiresearchNoen
local.conference.venueSuntec Singapore Convention & Exhibition Centre 1 Raffles Blvd, Singapore 039593en
local.sensitive.culturalNoen
local.year.published2024en
local.fileurl.openhttps://rune.une.edu.au/web/retrieve/9c0ea547-5601-4fec-acae-d3afb87eab52en
local.fileurl.openhttps://rune.une.edu.au/web/retrieve/6b38ffb2-feca-4412-bb1a-fe6c8ace6ff5en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/9c0ea547-5601-4fec-acae-d3afb87eab52en
local.subject.for20203209 Neurosciencesen
local.date.start2024-05-04-
local.date.end2024-05-09-
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.date.moved2025-01-20en
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