Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/64317
Title: Relationship Between Steroid Hormone Profile and Premenstrual Syndrome in Women Consulting for Infertility or Recurrent Miscarriage
Contributor(s): Turner, Joseph V  (author)orcid ; McLindon, Lucas A (author); Turner, Damien V (author); Alefsen, Yolaine (author); Ecochard, René (author)
Publication Date: 2024-03
Early Online Version: 2023-10-18
Open Access: Yes
DOI: 10.1007/s43032-023-01375-w
Handle Link: https://hdl.handle.net/1959.11/64317
Abstract: 

To determine the relationships between luteal-phase steroidal hormonal profile and PMS for a large number of women attending a dedicated fertility clinic. This was a retrospective cross-sectional study on women attending a hospital-based clinic for fertility concerns and/or recurrent miscarriage. All participants were assessed with a women's health questionnaire which also included evaluation of premenstrual symptoms. Day of ovulation was identified based on the peak mucus symptom assessed by the woman after instruction in a fertility awareness-based method (FABM). This enabled reliable timing of luteal-phase serum hormone levels to be taken and analysed. Between 2011 and 2021, 894 of the 2666 women undertaking the women's health assessment had at least one evaluable serum luteal hormone test. Serum progesterone levels were up to 10 nmol/L lower for symptomatic women compared with asymptomatic women. This difference was statistically significant (p < 0.05) for the majority of PMS symptoms at ≥ 9 days after the peak mucus symptom. A similar trend was observed for oestradiol but differences were generally not statistically significant. ROC curves demonstrated that steroid levels during the luteal phase were not discriminating in identifying the presence of PMS symptoms. Blood levels for progesterone were lower throughout the luteal phase in women with PMS, with the greatest effect seen late in the luteal phase.

Publication Type: Journal Article
Source of Publication: Reproductive Sciences, 31(3), p. 736-745
Publisher: Springer
Place of Publication: Germany
ISSN: 1933-7205
1933-7191
Fields of Research (FoR) 2020: 3215 Reproductive medicine
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Rural Medicine

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