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https://hdl.handle.net/1959.11/61685
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Wing-Hin | en |
dc.contributor.author | Bebawy, Mary | en |
dc.contributor.author | Loo, Ching-Yee | en |
dc.contributor.author | Luk, Frederick | en |
dc.contributor.author | Mason, Rebecca S | en |
dc.contributor.author | Rohanizadeh, Ramin | en |
dc.date.accessioned | 2024-07-16T23:09:38Z | - |
dc.date.available | 2024-07-16T23:09:38Z | - |
dc.date.issued | 2015-06-06 | - |
dc.identifier.citation | Journal of Biomedical Nanotechnology, 11(6), p. 1093-1105 | en |
dc.identifier.issn | 1550-7041 | en |
dc.identifier.issn | 1550-7033 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/61685 | - |
dc.description.abstract | <p>Although curcumin is effective in killing cancer cells, its low water solubility and inadequate bioavailability remain major limitations to its therapeutic application. Formulating curcumin micellar nanoparticles (Cur-NPs) encapsulated with a biodegradable polymer can significantly improve curcumin's solubility, stability, and bioavailability in vitro. In this study, differently sized Cur-NPs coated with polyvinyl alcohol (PVA) were engineered. The particle size, encapsulation efficiency, in vitro release, stability, cytotoxicity, and cellular uptake of these Cur-NPs were characterized in several cancer cell lines. The results showed that, relative to solubilized curcumin, Cur-NPs demonstrated higher cytotoxicity against cancer cells. To our knowledge, this study is the first to demonstrate that the extent of the anti-cancer potency and cellular uptake of Cur-NPs is directly correlated to particle size, where Cur-NPs with the smallest size (28 nm) were the most potent. Confocal microscopy revealed the subcellular localization of the smaller Cur-NPs (28 nm) to be in both the nucleus and cytoplasm, while the larger particles (200 nm) were only localized in the cytoplasm.</p> | en |
dc.language | en | en |
dc.publisher | American Scientific Publishers | en |
dc.relation.ispartof | Journal of Biomedical Nanotechnology | en |
dc.title | Fabrication of Curcumin Micellar Nanoparticles with Enhanced Anti-Cancer Activity | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1166/jbn.2015.2041 | en |
local.contributor.firstname | Wing-Hin | en |
local.contributor.firstname | Mary | en |
local.contributor.firstname | Ching-Yee | en |
local.contributor.firstname | Frederick | en |
local.contributor.firstname | Rebecca S | en |
local.contributor.firstname | Ramin | en |
local.profile.school | School of Psychology | en |
local.profile.email | mbebawy@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United States of America | en |
local.identifier.runningnumber | 13 | en |
local.format.startpage | 1093 | en |
local.format.endpage | 1105 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 11 | en |
local.identifier.issue | 6 | en |
local.contributor.lastname | Lee | en |
local.contributor.lastname | Bebawy | en |
local.contributor.lastname | Loo | en |
local.contributor.lastname | Luk | en |
local.contributor.lastname | Mason | en |
local.contributor.lastname | Rohanizadeh | en |
dc.identifier.staff | une-id:mbebawy | en |
local.profile.orcid | 0000-0003-2606-921X | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/61685 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Fabrication of Curcumin Micellar Nanoparticles with Enhanced Anti-Cancer Activity | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Lee, Wing-Hin | en |
local.search.author | Bebawy, Mary | en |
local.search.author | Loo, Ching-Yee | en |
local.search.author | Luk, Frederick | en |
local.search.author | Mason, Rebecca S | en |
local.search.author | Rohanizadeh, Ramin | en |
local.uneassociation | No | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.year.published | 2015 | en |
local.subject.for2020 | 3208 Medical physiology | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.date.moved | 2024-08-01 | en |
Appears in Collections: | Journal Article School of Psychology |
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