Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/60482
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dc.contributor.authorIsbister, Geoffrey Ken
dc.contributor.authorMaduwage, Kalanaen
dc.contributor.authorScorgie, Fiona Een
dc.contributor.authorShahmy, Seyeden
dc.contributor.authorMohamed, Fahimen
dc.contributor.authorAbeysinghe, Chandanaen
dc.contributor.authorKarunathilake, Harendraen
dc.contributor.authorO’Leary, Margaret Aen
dc.contributor.authorGnanathasan, Christeine Aen
dc.contributor.authorLincz, Lisa Fen
dc.date.accessioned2024-06-04T01:38:45Z-
dc.date.available2024-06-04T01:38:45Z-
dc.date.issued2015-08-21-
dc.identifier.citationPLoS neglected tropical diseases, 9(8), p. 1-12en
dc.identifier.issn1935-2735en
dc.identifier.urihttps://hdl.handle.net/1959.11/60482-
dc.description.abstract<p><b>Background</b></p> <p>Russell’s viper envenoming is a major problem in South Asia and causes venom induced consumption coagulopathy. This study aimed to investigate the kinetics and dynamics of venom and clotting function in Russell’s viper envenoming.</p> <p><b>Methodology/Principal Findings</b></p> <p>In a prospective cohort of 146 patients with Russell’s viper envenoming, we measured venom concentrations, international normalised ratio [INR], prothrombin time (PT), activated partial thromboplastin time (aPTT), coagulation factors I, II, V, VII, VIII, IX and X, and von Willebrand factor antigen. The median age was 39y (16–82y) and 111 were male. The median peak INR was 6.8 (interquartile range[IQR]:3.7 to >13), associated with low fibrinogen [median,<0.01g/L; IQR:<0.01–0.9g/L), low factor V levels [median,<5%; IQR:<5–4%], low factor VIII levels [median,40%; IQR:12–79%] and low factor X levels [median,48%; IQR:29–67%]. There were smaller reductions in factors II, IX and VII over time. All factors recovered over 48h post-antivenom. The median INR remained >3 at 6h post-antivenom but had reduced to <2, by 24h. The aPTT had also returned to close to normal (<50sec) at 24h. Factor VII, VIII and IX levels were unusually high pre-antivenom, median peak concentrations of 393%, 307% and 468% respectively. Pre-antivenom venom concentrations and the INR (r = 0.20, p = 0.02) and aPTT (r = 0.19, p = 0.03) were correlated (non-parametric Spearman analysis).</p> <p><b>Conclusions</b></p> <p>Russell’s viper coagulopathy results in prolonged aPTT, INR, low fibrinogen, factors V, VIII and X which recover over 48h. Severity of clotting abnormalities was associated with venom concentrations.</p>en
dc.languageenen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofPLoS neglected tropical diseasesen
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleVenom Concentrations and Clotting Factor Levels in a Prospective Cohort of Russell’s Viper Bites with Coagulopathyen
dc.typeJournal Articleen
dc.identifier.doi10.1371/journal.pntd.0003968en
dcterms.accessRightsUNE Greenen
local.contributor.firstnameGeoffrey Ken
local.contributor.firstnameKalanaen
local.contributor.firstnameFiona Een
local.contributor.firstnameSeyeden
local.contributor.firstnameFahimen
local.contributor.firstnameChandanaen
local.contributor.firstnameHarendraen
local.contributor.firstnameMargaret Aen
local.contributor.firstnameChristeine Aen
local.contributor.firstnameLisa Fen
local.relation.isfundedbyNHMRCen
local.relation.isfundedbyNHMRCen
local.profile.schoolSchool of Science & Technologyen
local.profile.emailkmaduwag@une.edu.auen
local.output.categoryC1en
local.grant.number631073en
local.grant.number1061041en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeUnited States of Americaen
local.identifier.runningnumbere0003968en
local.format.startpage1en
local.format.endpage12en
local.peerreviewedYesen
local.identifier.volume9en
local.identifier.issue8en
local.access.fulltextYesen
local.contributor.lastnameIsbisteren
local.contributor.lastnameMaduwageen
local.contributor.lastnameScorgieen
local.contributor.lastnameShahmyen
local.contributor.lastnameMohameden
local.contributor.lastnameAbeysingheen
local.contributor.lastnameKarunathilakeen
local.contributor.lastnameO’Learyen
local.contributor.lastnameGnanathasanen
local.contributor.lastnameLinczen
dc.identifier.staffune-id:kmaduwagen
local.profile.orcid0000-0001-5351-808Xen
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local.identifier.unepublicationidune:1959.11/60482en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleVenom Concentrations and Clotting Factor Levels in a Prospective Cohort of Russell’s Viper Bites with Coagulopathyen
local.relation.fundingsourcenoteThe study was supported in part by by IRQUE Project Grant.en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.relation.grantdescriptionNHMRC/631073en
local.relation.grantdescriptionNHMRC/1061041en
local.search.authorIsbister, Geoffrey Ken
local.search.authorMaduwage, Kalanaen
local.search.authorScorgie, Fiona Een
local.search.authorShahmy, Seyeden
local.search.authorMohamed, Fahimen
local.search.authorAbeysinghe, Chandanaen
local.search.authorKarunathilake, Harendraen
local.search.authorO’Leary, Margaret Aen
local.search.authorGnanathasan, Christeine Aen
local.search.authorLincz, Lisa Fen
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/c49931d3-3fb4-4607-856f-1e1ab36dc0aden
local.uneassociationNoen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.year.published2015-
local.fileurl.openhttps://rune.une.edu.au/web/retrieve/c49931d3-3fb4-4607-856f-1e1ab36dc0aden
local.fileurl.openpublishedhttps://rune.une.edu.au/web/retrieve/c49931d3-3fb4-4607-856f-1e1ab36dc0aden
local.subject.for20203205 Medical biochemistry and metabolomicsen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.date.moved2024-06-04en
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