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https://hdl.handle.net/1959.11/60482
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DC Field | Value | Language |
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dc.contributor.author | Isbister, Geoffrey K | en |
dc.contributor.author | Maduwage, Kalana | en |
dc.contributor.author | Scorgie, Fiona E | en |
dc.contributor.author | Shahmy, Seyed | en |
dc.contributor.author | Mohamed, Fahim | en |
dc.contributor.author | Abeysinghe, Chandana | en |
dc.contributor.author | Karunathilake, Harendra | en |
dc.contributor.author | O’Leary, Margaret A | en |
dc.contributor.author | Gnanathasan, Christeine A | en |
dc.contributor.author | Lincz, Lisa F | en |
dc.date.accessioned | 2024-06-04T01:38:45Z | - |
dc.date.available | 2024-06-04T01:38:45Z | - |
dc.date.issued | 2015-08-21 | - |
dc.identifier.citation | PLoS neglected tropical diseases, 9(8), p. 1-12 | en |
dc.identifier.issn | 1935-2735 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/60482 | - |
dc.description.abstract | <p><b>Background</b></p> <p>Russell’s viper envenoming is a major problem in South Asia and causes venom induced consumption coagulopathy. This study aimed to investigate the kinetics and dynamics of venom and clotting function in Russell’s viper envenoming.</p> <p><b>Methodology/Principal Findings</b></p> <p>In a prospective cohort of 146 patients with Russell’s viper envenoming, we measured venom concentrations, international normalised ratio [INR], prothrombin time (PT), activated partial thromboplastin time (aPTT), coagulation factors I, II, V, VII, VIII, IX and X, and von Willebrand factor antigen. The median age was 39y (16–82y) and 111 were male. The median peak INR was 6.8 (interquartile range[IQR]:3.7 to >13), associated with low fibrinogen [median,<0.01g/L; IQR:<0.01–0.9g/L), low factor V levels [median,<5%; IQR:<5–4%], low factor VIII levels [median,40%; IQR:12–79%] and low factor X levels [median,48%; IQR:29–67%]. There were smaller reductions in factors II, IX and VII over time. All factors recovered over 48h post-antivenom. The median INR remained >3 at 6h post-antivenom but had reduced to <2, by 24h. The aPTT had also returned to close to normal (<50sec) at 24h. Factor VII, VIII and IX levels were unusually high pre-antivenom, median peak concentrations of 393%, 307% and 468% respectively. Pre-antivenom venom concentrations and the INR (r = 0.20, p = 0.02) and aPTT (r = 0.19, p = 0.03) were correlated (non-parametric Spearman analysis).</p> <p><b>Conclusions</b></p> <p>Russell’s viper coagulopathy results in prolonged aPTT, INR, low fibrinogen, factors V, VIII and X which recover over 48h. Severity of clotting abnormalities was associated with venom concentrations.</p> | en |
dc.language | en | en |
dc.publisher | Public Library of Science | en |
dc.relation.ispartof | PLoS neglected tropical diseases | en |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Venom Concentrations and Clotting Factor Levels in a Prospective Cohort of Russell’s Viper Bites with Coagulopathy | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1371/journal.pntd.0003968 | en |
dcterms.accessRights | UNE Green | en |
local.contributor.firstname | Geoffrey K | en |
local.contributor.firstname | Kalana | en |
local.contributor.firstname | Fiona E | en |
local.contributor.firstname | Seyed | en |
local.contributor.firstname | Fahim | en |
local.contributor.firstname | Chandana | en |
local.contributor.firstname | Harendra | en |
local.contributor.firstname | Margaret A | en |
local.contributor.firstname | Christeine A | en |
local.contributor.firstname | Lisa F | en |
local.relation.isfundedby | NHMRC | en |
local.relation.isfundedby | NHMRC | en |
local.profile.school | School of Science & Technology | en |
local.profile.email | kmaduwag@une.edu.au | en |
local.output.category | C1 | en |
local.grant.number | 631073 | en |
local.grant.number | 1061041 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United States of America | en |
local.identifier.runningnumber | e0003968 | en |
local.format.startpage | 1 | en |
local.format.endpage | 12 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 9 | en |
local.identifier.issue | 8 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Isbister | en |
local.contributor.lastname | Maduwage | en |
local.contributor.lastname | Scorgie | en |
local.contributor.lastname | Shahmy | en |
local.contributor.lastname | Mohamed | en |
local.contributor.lastname | Abeysinghe | en |
local.contributor.lastname | Karunathilake | en |
local.contributor.lastname | O’Leary | en |
local.contributor.lastname | Gnanathasan | en |
local.contributor.lastname | Lincz | en |
dc.identifier.staff | une-id:kmaduwag | en |
local.profile.orcid | 0000-0001-5351-808X | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/60482 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Venom Concentrations and Clotting Factor Levels in a Prospective Cohort of Russell’s Viper Bites with Coagulopathy | en |
local.relation.fundingsourcenote | The study was supported in part by by IRQUE Project Grant. | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.relation.grantdescription | NHMRC/631073 | en |
local.relation.grantdescription | NHMRC/1061041 | en |
local.search.author | Isbister, Geoffrey K | en |
local.search.author | Maduwage, Kalana | en |
local.search.author | Scorgie, Fiona E | en |
local.search.author | Shahmy, Seyed | en |
local.search.author | Mohamed, Fahim | en |
local.search.author | Abeysinghe, Chandana | en |
local.search.author | Karunathilake, Harendra | en |
local.search.author | O’Leary, Margaret A | en |
local.search.author | Gnanathasan, Christeine A | en |
local.search.author | Lincz, Lisa F | en |
local.open.fileurl | https://rune.une.edu.au/web/retrieve/c49931d3-3fb4-4607-856f-1e1ab36dc0ad | en |
local.uneassociation | No | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.year.published | 2015 | - |
local.fileurl.open | https://rune.une.edu.au/web/retrieve/c49931d3-3fb4-4607-856f-1e1ab36dc0ad | en |
local.fileurl.openpublished | https://rune.une.edu.au/web/retrieve/c49931d3-3fb4-4607-856f-1e1ab36dc0ad | en |
local.subject.for2020 | 3205 Medical biochemistry and metabolomics | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.profile.affiliationtype | External Affiliation | en |
local.date.moved | 2024-06-04 | en |
Appears in Collections: | Journal Article School of Science and Technology |
Files in This Item:
File | Description | Size | Format | |
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openpublished/VenomMaduwage2015JournalArticle.pdf | Published Version | 730.47 kB | Adobe PDF Download Adobe | View/Open |
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