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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/59650
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dc.contributor.authorFletcher, Erica Len
dc.contributor.authorWang, Anna Yen
dc.contributor.authorJobling, Andrew Ien
dc.contributor.authorRutar, Matthew Ven
dc.contributor.authorGreferath, Ursulaen
dc.contributor.authorGu, Benen
dc.contributor.authorVessey, Kirstan Aen
dc.date.accessioned2024-05-22T01:41:05Z-
dc.date.available2024-05-22T01:41:05Z-
dc.date.issued2019-
dc.identifier.citationDrug Discovery Today, 24(8), p. 1598-1605en
dc.identifier.issn1878-5832en
dc.identifier.issn1359-6446en
dc.identifier.urihttps://hdl.handle.net/1959.11/59650-
dc.description.abstract<p>Age-related macular degeneration and glaucoma are the commonest causes of irreversible vision loss in industrialized countries. The purine ATP is known to regulate a range of cellular functions in the retina via its action on P2 receptors, especially the P2X7 receptor. Although agents that attenuate P2X7 receptor function have been in development for many years, no compound is currently approved for the treatment of eye disease. However, newer compounds that cross the blood-brain barrier could have potential to reduce vision loss. This review will outline recent information relating to the role of P2X7 in age-related macular degeneration and glaucoma and, subsequently, we will discuss recent developments for attenuating P2X7 receptor function.</p>en
dc.languageenen
dc.publisherElsevier Ltd. * Trends Journalsen
dc.relation.ispartofDrug Discovery Todayen
dc.titleTargeting P2X7 receptors as a means for treating retinal diseaseen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.drudis.2019.03.029en
local.contributor.firstnameErica Len
local.contributor.firstnameAnna Yen
local.contributor.firstnameAndrew Ien
local.contributor.firstnameMatthew Ven
local.contributor.firstnameUrsulaen
local.contributor.firstnameBenen
local.contributor.firstnameKirstan Aen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailkvessey@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeUnited Kingdomen
local.format.startpage1598en
local.format.endpage1605en
local.peerreviewedYesen
local.identifier.volume24en
local.identifier.issue8en
local.contributor.lastnameFletcheren
local.contributor.lastnameWangen
local.contributor.lastnameJoblingen
local.contributor.lastnameRutaren
local.contributor.lastnameGreferathen
local.contributor.lastnameGuen
local.contributor.lastnameVesseyen
dc.identifier.staffune-id:kvesseyen
local.profile.orcid0000-0003-1031-1964en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/59650en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleTargeting P2X7 receptors as a means for treating retinal diseaseen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorFletcher, Erica Len
local.search.authorWang, Anna Yen
local.search.authorJobling, Andrew Ien
local.search.authorRutar, Matthew Ven
local.search.authorGreferath, Ursulaen
local.search.authorGu, Benen
local.search.authorVessey, Kirstan Aen
local.uneassociationNoen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.year.published2019en
local.subject.for20203209 Neurosciencesen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.date.moved2024-06-14en
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