1. Research UNE
  2. UNE
  3. Journal Article
Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/58928
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMa, Jessica Y Wen
dc.contributor.authorGreferath, Ursulaen
dc.contributor.authorWong, Josephine H Cen
dc.contributor.authorFothergill, Linda Jen
dc.contributor.authorJobling, Andrew Ien
dc.contributor.authorVessey, Kirstan Aen
dc.contributor.authorFletcher, Erica Len
dc.date.accessioned2024-05-03T03:54:37Z-
dc.date.available2024-05-03T03:54:37Z-
dc.date.issued2023-
dc.identifier.citationNeurobiology of Aging, v.128, p. 1-16en
dc.identifier.issn1558-1497en
dc.identifier.issn0197-4580en
dc.identifier.urihttps://hdl.handle.net/1959.11/58928-
dc.description.abstract<p>Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss and dysfunction in the retinal pigment epithelium (RPE) with age is known to contribute to disease development. The aim of this study was to investigate how the C57BL/6J mouse RPE changes with age. RPE structure was found to change with age and eccentricity, with cell size increasing, nuclei lost, and tight junctions altered in the peripheral retina. Phagocytosis of photoreceptor outer segments (POS) by the RPE was investigated using gene expression analysis and histology. RNA-Seq transcriptomic gene profiling of the RPE showed a downregulation of genes involved in phagosome processing and histological analysis showed a decline in phagosome-lysosome association in the aged tissue. In addition, failures in the autophagy pathway that modulates intracellular waste degradation were observed in the aged RPE tissue. These findings highlight that RPE cell loss and slowing of POS processing contribute to RPE dysfunction with age and may predispose the aging eye to AMD development.</p>en
dc.languageenen
dc.publisherElsevier Incen
dc.relation.ispartofNeurobiology of Agingen
dc.titleAging induces cell loss and a decline in phagosome processing in the mouse retinal pigment epitheliumen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.neurobiolaging.2023.03.003en
local.contributor.firstnameJessica Y Wen
local.contributor.firstnameUrsulaen
local.contributor.firstnameJosephine H Cen
local.contributor.firstnameLinda Jen
local.contributor.firstnameAndrew Ien
local.contributor.firstnameKirstan Aen
local.contributor.firstnameErica Len
local.relation.isfundedbyNHMRCen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailkvessey@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeUnited States of Americaen
local.format.startpage1en
local.format.endpage16en
local.peerreviewedYesen
local.identifier.volume128en
local.contributor.lastnameMaen
local.contributor.lastnameGreferathen
local.contributor.lastnameWongen
local.contributor.lastnameFothergillen
local.contributor.lastnameJoblingen
local.contributor.lastnameVesseyen
local.contributor.lastnameFletcheren
dc.identifier.staffune-id:kvesseyen
local.profile.orcid0000-0003-1031-1964en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/58928en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleAging induces cell loss and a decline in phagosome processing in the mouse retinal pigment epitheliumen
local.relation.fundingsourcenoteAPP1181010 APP1138253en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorMa, Jessica Y Wen
local.search.authorGreferath, Ursulaen
local.search.authorWong, Josephine H Cen
local.search.authorFothergill, Linda Jen
local.search.authorJobling, Andrew Ien
local.search.authorVessey, Kirstan Aen
local.search.authorFletcher, Erica Len
local.uneassociationNoen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.year.published2023en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/a8fe76f0-7277-4d8d-9301-83769c1a2ebden
local.subject.for2020320907 Sensory systemsen
local.subject.for2020321204 Vision scienceen
local.subject.seo2020280103 Expanding knowledge in the biomedical and clinical sciencesen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.date.moved2024-05-03en
Appears in Collections:Journal Article
School of Science and Technology
Files in This Item:
1 files
File SizeFormat 
Show simple item record

SCOPUSTM   
Citations

6
checked on Dec 28, 2024
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.