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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/58839
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dc.contributor.authorWilliams, Natasha Len
dc.contributor.authorMorris, Jodie Len
dc.contributor.authorRush, Catherine Men
dc.contributor.authorKetheesan, Natkunamen
dc.date.accessioned2024-05-01T05:36:58Z-
dc.date.available2024-05-01T05:36:58Z-
dc.date.issued2015-04-
dc.identifier.citationMicrobes and Infection, 17(4), p. 311-316en
dc.identifier.issn1769-714Xen
dc.identifier.issn1286-4579en
dc.identifier.urihttps://hdl.handle.net/1959.11/58839-
dc.description.abstract<p>Melioidosis sepsis, caused by <i>Burkholderia pseudomallei</i>, is associated with high mortality due to an overwhelming inflammatory response. Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons (IFN). This study investigated whether pDC and type I IFN play a role during the early stages of <i>B. pseudomallei</i> infection. Human and murine pDC internalised and killed <i>B. pseudomallei</i> as efficiently as murine conventional DC (cDC). pDC derived from <i>B. pseudomallei</i>-susceptible (BALB/c) mice demonstrated poor intracellular killing and increased IFN-alpha compared to pDC derived from <i>B. pseudomallei</i>-resistant (C57BL/6) mice. This is the first evidence of pDC bactericidal activity against <i>B. pseudomallei</i> infection.</p>en
dc.languageenen
dc.publisherElsevier Massonen
dc.relation.ispartofMicrobes and Infectionen
dc.titlePlasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomalleien
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.micinf.2014.12.007en
local.contributor.firstnameNatasha Len
local.contributor.firstnameJodie Len
local.contributor.firstnameCatherine Men
local.contributor.firstnameNatkunamen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailnkethees@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeFranceen
local.format.startpage311en
local.format.endpage316en
local.peerreviewedYesen
local.identifier.volume17en
local.identifier.issue4en
local.contributor.lastnameWilliamsen
local.contributor.lastnameMorrisen
local.contributor.lastnameRushen
local.contributor.lastnameKetheesanen
dc.identifier.staffune-id:nketheesen
local.profile.orcid0000-0002-4870-706Xen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/58839en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitlePlasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomalleien
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorWilliams, Natasha Len
local.search.authorMorris, Jodie Len
local.search.authorRush, Catherine Men
local.search.authorKetheesan, Natkunamen
local.uneassociationYesen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.year.published2015en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/f6f3490e-f19d-4c6f-9efe-83bcd5509da7en
local.subject.for20203202 Infectious diseasesen
local.subject.seo2020tbden
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.date.moved2024-05-01en
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