Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/58607
Full metadata record
DC FieldValueLanguage
dc.contributor.authorShadli, Shabah Men
dc.contributor.authorAndo, Lynne Cen
dc.contributor.authorMcIntosh, Juliaen
dc.contributor.authorLodhia, Veemaen
dc.contributor.authorRussell, Bruce Ren
dc.contributor.authorKirk, Ian Jen
dc.contributor.authorGlue, Paulen
dc.contributor.authorMcNaughton, Neilen
dc.date.accessioned2024-04-24T00:29:46Z-
dc.date.available2024-04-24T00:29:46Z-
dc.date.issued2021-
dc.identifier.citationScientific Reports, v.11en
dc.identifier.issn2045-2322en
dc.identifier.urihttps://hdl.handle.net/1959.11/58607-
dc.description.abstract<p><b>Psychiatric diagnoses currently rely on a patient's presenting symptoms or signs, lacking muchneeded theory-based biomarkers. Our neuropsychological theory of anxiety, recently supported by human imaging, is founded on a longstanding, reliable, rodent 'theta' brain rhythm model of human clinical anxiolytic drug action. We have now developed a human scalp EEG homolog—goal-confictspecifc rhythmicity (GCSR), i.e., EEG rhythmicity specifc to a balanced confict between goals (e.g., approach-avoidance). Critically, GCSR is consistently reduced by diferent classes of anxiolytic drug and correlates with clinically-relevant trait anxiety scores (STAI-T). Here we show elevated GCSR in student volunteers divided, after testing, on their STAI-T scores into low, medium, and high (typical of clinical anxiety) groups. We then tested anxiety disorder patients (meeting diagnostic criteria) and similar controls recruited separately from the community. The patient group had higher average GCSR than their controls—with a mixture of high and low GCSR that varied with, but cut across, conventional disorder diagnosis. Consequently, GCSR scores should provide the frst theoretically based biomarker that could help diagnose, and so redefne, a psychiatric disorder.</b></p>en
dc.languageenen
dc.publisherNature Publishing Groupen
dc.relation.ispartofScientific Reportsen
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleRight frontal anxiolytic-sensitive EEG ‘theta’ rhythm in the stop-signal task is a theory-based anxiety disorder biomarkeren
dc.typeJournal Articleen
dc.identifier.doi10.1038/s41598-021-99374-xen
local.contributor.firstnameShabah Men
local.contributor.firstnameLynne Cen
local.contributor.firstnameJuliaen
local.contributor.firstnameVeemaen
local.contributor.firstnameBruce Ren
local.contributor.firstnameIan Jen
local.contributor.firstnamePaulen
local.contributor.firstnameNeilen
local.profile.schoolSchool of Science & Technologyen
local.profile.emailsshadli@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeUnited Kingdomen
local.identifier.runningnumber19746en
local.peerreviewedYesen
local.identifier.volume11en
local.access.fulltextYesen
local.contributor.lastnameShadlien
local.contributor.lastnameAndoen
local.contributor.lastnameMcIntoshen
local.contributor.lastnameLodhiaen
local.contributor.lastnameRussellen
local.contributor.lastnameKirken
local.contributor.lastnameGlueen
local.contributor.lastnameMcNaughtonen
dc.identifier.staffune-id:sshadlien
local.profile.orcid0000-0002-3607-3469en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/58607en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleRight frontal anxiolytic-sensitive EEG ‘theta’ rhythm in the stop-signal task is a theory-based anxiety disorder biomarkeren
local.relation.fundingsourcenoteHealth Research Council of New Zealand.en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorShadli, Shabah Men
local.search.authorAndo, Lynne Cen
local.search.authorMcIntosh, Juliaen
local.search.authorLodhia, Veemaen
local.search.authorRussell, Bruce Ren
local.search.authorKirk, Ian Jen
local.search.authorGlue, Paulen
local.search.authorMcNaughton, Neilen
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/209cdc72-c297-46ec-abf2-088e438283d7en
local.uneassociationNoen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.year.published2021en
local.fileurl.openhttps://rune.une.edu.au/web/retrieve/209cdc72-c297-46ec-abf2-088e438283d7en
local.fileurl.openpublishedhttps://rune.une.edu.au/web/retrieve/209cdc72-c297-46ec-abf2-088e438283d7en
local.subject.for20203209 Neurosciencesen
local.subject.seo2020tbden
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.profile.affiliationtypeExternal Affiliationen
local.date.moved2024-04-24en
Appears in Collections:Journal Article
School of Science and Technology
Files in This Item:
2 files
File Description SizeFormat 
openpublished/RightShadli2021JournalArticle.pdfPublished version1.99 MBAdobe PDF
Download Adobe
View/Open
Show simple item record

SCOPUSTM   
Citations

24
checked on Dec 28, 2024
Google Media

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons