Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/57207
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dc.contributor.authorGlover, Stephen Aen
dc.date.accessioned2024-01-08T06:49:42Z-
dc.date.available2024-01-08T06:49:42Z-
dc.date.issued2023-01-19-
dc.identifier.citationAustralian Journal of Chemistry, 76(1), p. 1-24en
dc.identifier.issn1445-0038en
dc.identifier.issn0004-9425en
dc.identifier.urihttps://hdl.handle.net/1959.11/57207-
dc.description.abstract<p>This account describes the origins of our extensive investigations into the mutagenicity of N-acyloxy-N-alkoxyamides. Since their discovery as biologically active anomeric amides that mutate DNA in the Ames reverse mutation assay without the need for metabolic activation, we have used activities in the Ames test to understand the impact of structural variation on cellular access to, binding to and reactivity with DNA. We have developed an understanding of the roles played by hydrophobicity, electrophilic reactivity, steric effects and, importantly, intercalation on mutagenicity levels and therefore interactions with DNA. The evolution and application of meaningful quantitative structure–activity relationships is described, and examples of their utility in explaining molecule–DNA interactions are given. Their ability to explain previous mutagenicity data and, importantly, to predict meaningful mutagenic behaviour is also demonstrated.</p>en
dc.languageenen
dc.publisherCSIRO Publishingen
dc.relation.ispartofAustralian Journal of Chemistryen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleMutagenicity of N-acyloxy-N-alkoxyamides – QSAR determination of factors controlling activityen
dc.typeJournal Articleen
dc.identifier.doi10.1071/CH22205en
dcterms.accessRightsUNE Greenen
local.contributor.firstnameStephen Aen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailsglover@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeAustraliaen
local.format.startpage1en
local.format.endpage24en
local.peerreviewedYesen
local.identifier.volume76en
local.identifier.issue1en
local.access.fulltextYesen
local.contributor.lastnameGloveren
dc.identifier.staffune-id:sgloveren
local.profile.orcid0000-0002-9344-8669en
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/57207en
dc.identifier.academiclevelAcademicen
local.title.maintitleMutagenicity of N-acyloxy-N-alkoxyamides – QSAR determination of factors controlling activityen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorGlover, Stephen Aen
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/e16bb113-8349-43c7-9516-672d36a592a9en
local.uneassociationYesen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.year.published2023en
local.fileurl.openhttps://rune.une.edu.au/web/retrieve/e16bb113-8349-43c7-9516-672d36a592a9en
local.fileurl.openpublishedhttps://rune.une.edu.au/web/retrieve/e16bb113-8349-43c7-9516-672d36a592a9en
local.subject.for2020340402 Biomolecular modelling and designen
local.subject.for2020340401 Biologically active moleculesen
local.subject.for2020340701 Computational chemistryen
local.subject.seo2020280105 Expanding knowledge in the chemical sciencesen
local.subject.seo2020280102 Expanding knowledge in the biological sciencesen
local.profile.affiliationtypeUNE Affiliationen
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School of Science and Technology
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