Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/5526
Title: The 'intD' mobile genetic element from 'Dichelobacter nodosus', the causative agent of ovine footrot, is associated with the benign phenotype
Contributor(s): Tanjung, Livia R (author); Whittle, Gabrielle (author); Shaw, Bruce E (author); Bloomfield, Garry A (author); Katz, Margaret E  (author); Cheetham, Brian F  (author)
Publication Date: 2009
DOI: 10.1016/j.anaerobe.2009.02.005
Handle Link: https://hdl.handle.net/1959.11/5526
Abstract: The Gram-negative anaerobic pathogen 'Dichelobacter nodosus' is the principal causative agent of footrot in sheep. The 'intA', 'intB' and 'intC' elements are mobile genetic elements which integrate into two tRNA genes downstream from 'csrA' (formerly 'glpA') and 'pnpA' in the 'D. nodosus' chromosome. CsrA homologues act as global repressors of virulence in several bacterial pathogens, as does polynucleotide phosphorylase, the product of 'pnpA'. We have proposed a model in which virulence in 'D. nodosus' is controlled in part by the integration of genetic elements downstream from 'csrA' and 'pnpA', altering the expression of these putative global regulators of virulence. We describe here a novel integrated genetic element, the 'intD' element, which is 32 kb in size and contains an integrase gene, 'intD', several genes related to genes on other integrated elements of 'D. nodosus', a type IV secretion system and a putative mobilisation region, suggesting that the 'intD' element has a role in the transfer of other genetic elements. Most of the 'D. nodosus' strains examined which contained the 'intD' gene were benign, with 'intD' integrated next to 'pnpA', supporting our previous observation that virulent strains of 'D. nodosus' have the 'intA' element next to 'pnpA'.
Publication Type: Journal Article
Source of Publication: Anaerobe, 15(5), p. 219-224
Publisher: Academic Press
Place of Publication: United Kingdom
ISSN: 1095-8274
1075-9964
Fields of Research (FoR) 2008: 060501 Bacteriology
070707 Veterinary Microbiology (excl Virology)
060503 Microbial Genetics
Socio-Economic Objective (SEO) 2008: 830311 Sheep - Wool
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

Files in This Item:
2 files
File Description SizeFormat 
Show full item record

SCOPUSTM   
Citations

3
checked on Mar 9, 2024

Page view(s)

1,098
checked on Jun 18, 2023
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.